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Comparative analysis of risk factors for acute graft-versus-host disease and for chronic graft-versus-host disease according to National Institutes of Health consensus criteria
Open accessAbstract
Risk factors for grades 2-4 acute graft-versus-host disease (GVHD) and for chronic GVHD as defined by National Institutes of Health consensus criteria were evaluated and compared in 2941 recipients of first allogeneic hematopoietic cell transplantation at our center. In multivariate analyses, the profiles of risk factors for acute and chronic GVHD were similar, with some notable differences. Recipient human leukocyte antigen (HLA) mismatching and the use of unrelated donors had a greater effect on the risk of acute GVHD than on chronic GVHD, whereas the use of female donors for male recipients had a greater effect on the risk of chronic GVHD than on acute GVHD. Total body irradiation was strongly associated with acute GVHD, but had no statistically significant association with chronic GVHD, whereas grafting with mobilized blood cells was strongly associated with chronic GVHD but not with acute GVHD. Older patient age was associated with chronic GVHD, but had no effect on acute GVHD. For all risk factors associated with chronic GVHD, point estimates and confidence intervals were not significantly changed after adjustment for prior acute GVHD. These results suggest that the mechanisms involved in acute and chronic GVHD are not entirely congruent and that chronic GVHD is not simply the end stage of acute GVHD.
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Cited by
Martin, P. J., Rizzo, J. D., Wingard, J. R., Ballen, K., Curtin, P. T., Cutler, C., Litzow, M. R., Nieto, Y., Savani, B. N., Schriber, J. R., et al. (2012) · Biology of Blood and Marrow Transplantation · doi:10.1016/j.bbmt.2012.04.005 · Cited by 641
Self-citationAdolescent and Young Adult Oncology, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology
Coccia, P. F., Pappo, A. S., Beaupin, L., Borges, V. F., Borinstein, S. C., Chugh, R., Dinner, S., Folbrecht, J., Frazier, A. L., Goldsby, R., et al. (2018) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2018.0001 · Cited by 295
Outcomes of acute leukemia patients transplanted with naive T cell–depleted stem cell grafts
Bleakley, M., Heimfeld, S., Loeb, K. R., Jones, L. A., Chaney, C., Seropian, S., Gooley, T. A., Sommermeyer, F., Riddell, S. R., & Shlomchik, W. D. (2015) · Journal of Clinical Investigation · doi:10.1172/jci81229 · Cited by 268
Acute graft-versus-host disease
Malard, F., Holler, E., Sandmaier, B. M., Huang, H., & Mohty, M. (2023) · Nature Reviews Disease Primers · doi:10.1038/s41572-023-00438-1 · Cited by 268
Blockade of Lymphocyte Chemotaxis in Visceral Graft-versus-Host Disease
Reshef, R., Luger, S. M., Hexner, E. O., Loren, A. W., Frey, N. V., Nasta, S. D., Goldstein, S. C., Stadtmauer, E. A., Smith, J., Bailey, S., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1201248 · Cited by 254
Metadata
- Authors
- Flowers, M. E. D., Inamoto, Y., Carpenter, P. A., Lee, S. J., Kiem, H.-P., Petersdorf, E. W., Pereira, S. E., Nash, R. A., Mielcarek, M., Fero, M. L., Warren, E. H., Sanders, J. E., Storb, R. F., Appelbaum, F. R., Storer, B. E., & Martin, P. J.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2011-03-17
- Volume
- 117
- Issue
- 11
- Pages
- 3214-3219
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2044560944
- Cited by
- 690
- References
- 0
- FWCI
- 25.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Flowers, M. E. D., Inamoto, Y., Carpenter, P. A., Lee, S. J., Kiem, H.-P., Petersdorf, E. W., Pereira, S. E., Nash, R. A., Mielcarek, M., Fero, M. L., Warren, E. H., Sanders, J. E., Storb, R. F., Appelbaum, F. R., Storer, B. E., & Martin, P. J. (2011). Comparative analysis of risk factors for acute graft-versus-host disease and for chronic graft-versus-host disease according to National Institutes of Health consensus criteria. Blood. https://doi.org/10.1182/blood-2010-08-302109
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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