Regulation of hepcidin expression at high altitude
Abstract
Enhanced erythropoietic drive and iron deficiency both influence iron homeostasis through the suppression of the iron regulatory hormone hepcidin. Hypoxia also suppresses hepcidin through a mechanism that is unknown. We measured iron indices and plasma hepcidin levels in healthy volunteers during a 7-day sojourn to high altitude (4340 m above sea level), with and without prior intravenous iron loading. Without prior iron loading, a rapid reduction in plasma hepcidin was observed that was almost complete by the second day at altitude. This occurred before any index of iron availability had changed. Prior iron loading delayed the decrease in hepcidin until after the transferrin saturation, but not the ferritin concentration, had normalized. We conclude that hepcidin suppression by the hypoxia of high altitude is not driven by a reduction in iron stores.
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Temporary increases in serum GDF15 levels were associated with increased serum EPO following ascent to high altitude.
“Furthermore, temporary increases in serum GDF15 levels associated with increased serum EPO following ascent to high altitude.”
From Regulation of erythropoiesis by hypoxia-inducible factors (2013) · cites this paper as [212]
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References 24 · Cited by 93
- Authors
- Talbot, N. P., Lakhal, S., Smith, T. G., Privat, C., Nickol, A. H., Rivera-Ch, M., León-Velarde, F., Dorrington, K. L., Mole, D. R., & Robbins, P. A.
- Affiliations
- Churchill Hospital (GB)
- Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom;
- John Radcliffe Hospital (GB)
- Universidad Peruana Cayetano Heredia (PE)
- Laboratory of High Altitude Adaptation, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru
- University of Oxford (GB)
- Corresponding author
- Talbot, Nick P.
- Smith, Thomas G.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2012-01-19
- Volume
- 119
- Issue
- 3
- Pages
- 857-860
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2021744317
- Cited by
- 93
- References
- 24
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 5 · 2020: 8 · 2019: 3 · 2018: 10 · 2017: 5 · 2016: 9 · 2015: 6 · 2014: 13 · 2013: 12 · 2012: 3
- FWCI
- 6.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › High Altitude and Hypoxia
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Keywords
- hepcidin, high altitude, hypoxia, iron homeostasis, iron deficiency, erythropoiesis, transferrin saturation, ferritin
- MeSH terms
- Adult, Altitude, Hypoxia, Erythropoiesis, Erythropoietin, Ferritins, Gene Expression Regulation, Homeostasis, Humans, Iron, Transferrin, Case-Control Studies, beta-Thalassemia, Iron Metabolism Disorders, Iron, Dietary, Antimicrobial Cationic Peptides, Growth Differentiation Factor 15, Hepcidins
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