The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans
Open accessAbstract
Chronic GVHD (cGVHD) poses a significant risk for HSCT patients. Preclinical development of new therapeutic modalities has been hindered by models with pathologic findings that may not simulate the development of human cGVHD. Previously, we have demonstrated that cGVHD induced by allogeneic HSCT after a conditioning regimen of cyclophosphamide and total-body radiation results in pulmonary dysfunction and airway obliteration, which leads to bronchiolitis obliterans (BO), which is pathognomonic for cGVHD of the lung. We now report cGVHD manifestations in a wide spectrum of target organs, including those with mucosal surfaces. Fibrosis was demonstrated in the lung and liver and was associated with CD4+ T cells and B220+ B-cell infiltration and alloantibody deposition. Donor bone marrow obtained from mice incapable of secreting IgG alloantibody resulted in less BO and cGVHD. Robust germinal center reactions were present at the time of cGVHD disease initiation. Blockade of germinal center formation with a lymphotoxin-receptor–immunoglobulin fusion protein suppressed cGVHD and BO. We conclude that cGVHD is caused in part by alloantibody secretion, which is associated with fibrosis and cGVHD manifestations including BO, and that treatment with a lymphotoxin-β receptor–immunoglobulin fusion protein could be beneficial for cGVHD prevention and therapy.
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Jagasia, M. H., Greinix, H. T., Arora, M., Williams, K. M., Wolff, D., Cowen, E. W., Palmer, J., Weisdorf, D., Treister, N. S., Cheng, G.-S., et al. (2015) · Biology of Blood and Marrow Transplantation · doi:10.1016/j.bbmt.2014.12.001 · Cited by 5,459
Filipovich, A. H., Weisdorf, D., Pavletic, S., Socie, G., Wingard, J. R., Lee, S. J., Martin, P., Chien, J., Przepiorka, D., Couriel, D., et al. (2005) · Biology of Blood and Marrow Transplantation · doi:10.1016/j.bbmt.2005.09.004 · Cited by 3,556
Chan, O. T. M., Hannum, L. G., Haberman, A. M., Madaio, M. P., & Shlomchik, M. J. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.10.1639 · Cited by 698
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Gong, Q., Ou, Q., Ye, S., Lee, W. P., Cornelius, J., Diehl, L., Lin, W. Y., Hu, Z., Lu, Y., Chen, Y., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.2.817 · Cited by 543
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Cutler, C., Miklos, D., Kim, H. T., Treister, N., Woo, S.-B., Bienfang, D., Klickstein, L. B., Levin, J., Miller, K., Reynolds, C., et al. (2006) · Blood · doi:10.1182/blood-2006-01-0233 · Cited by 452
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Sarantopoulos, S., Stevenson, K. E., Kim, H. T., Cutler, C. S., Bhuiya, N. S., Schowalter, M., Ho, V. T., Alyea, E. P., Koreth, J., Blazar, B. R., et al. (2009) · Blood · doi:10.1182/blood-2008-09-177840 · Cited by 319
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Gommerman, J. L., & Browning, J. L. (2003) · Nature Reviews Immunology · doi:10.1038/nri1151 · Cited by 292
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Browning, J. L. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2085 · Cited by 279
Self-citationAttenuated liver fibrosis in the absence of B cells
Novobrantseva, T. I. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24798 · Cited by 277
Cited by
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Metadata
- Authors
- Srinivasan, M., Flynn, R., Price, A., Ranger, A., Browning, J. L., Taylor, P. A., Ritz, J., Antin, J. H., Murphy, W. J., Luznik, L., Shlomchik, M. J., Panoskaltsis-Mortari, A., & Blazar, B. R.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2012-02-09
- Volume
- 119
- Issue
- 6
- Pages
- 1570-1580
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2042030389
- Cited by
- 260
- References
- 33
- FWCI
- 7.92
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans. https://app.cochat.ai/papers/10.1182/blood-2011-07-364414
- The paper
- Srinivasan, M., Flynn, R., Price, A., Ranger, A., Browning, J. L., Taylor, P. A., Ritz, J., Antin, J. H., Murphy, W. J., Luznik, L., Shlomchik, M. J., Panoskaltsis-Mortari, A., & Blazar, B. R. (2012). Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans. Blood. https://doi.org/10.1182/blood-2011-07-364414
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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