The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non–transferrin-bound iron
Open accessAbstract
Transfusions of RBCs stored for longer durations are associated with adverse effects in hospitalized patients. We prospectively studied 14 healthy human volunteers who donated standard leuko-reduced, double RBC units. One unit was autologously transfused “fresh” (3-7 days of storage), and the other “older” unit was transfused after 40 to 42 days of storage. Of the routine laboratory parameters measured at defined times surrounding transfusion, significant differences between fresh and older transfusions were only observed in iron parameters and markers of extravascular hemolysis. Compared with fresh RBCs, mean serum total bilirubin increased by 0.55 mg/dL at 4 hours after transfusion of older RBCs (P = .0003), without significant changes in haptoglobin or lactate dehydrogenase. In addition, only after the older transfusion, transferrin saturation increased progressively over 4 hours to a mean of 64%, and non–transferrin-bound iron appeared, reaching a mean of 3.2μM. The increased concentrations of non–transferrin-bound iron correlated with enhanced proliferation in vitro of a pathogenic strain of Escherichia coli (r = 0.94, P = .002). Therefore, circulating non–transferrin-bound iron derived from rapid clearance of transfused, older stored RBCs may enhance transfusion-related complications, such as infection. The trial was registered with www.clinicaltrials.gov as #NCT01319552.
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Sazawal, S., Black, R. E., Ramsan, M., Chwaya, H. M., Stoltzfus, R. J., Dutta, A., Dhingra, U., Kabole, I., Deb, S., Othman, M. K., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)67962-2 · Cited by 981
Cited by
Schaer, D. J., Buehler, P. W., Alayash, A. I., Belcher, J. D., & Vercellotti, G. M. (2013) · Blood · doi:10.1182/blood-2012-11-451229 · Cited by 754
Iron in infection and immunity
Nairz, M., & Weiss, G. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100864 · Cited by 359
Baek, J. H., D’Agnillo, F., Vallelian, F., Pereira, C. P., Williams, M. C., Jia, Y., Schaer, D. J., & Buehler, P. W. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59770 · Cited by 280
Schaer, D. J., & Buehler, P. W. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a013433 · Cited by 96
Labile plasma iron levels predict survival in patients with lower-risk myelodysplastic syndromes
de Swart, L., Reiniers, C., Bagguley, T., van Marrewijk, C., Bowen, D., Hellström-Lindberg, E., Tatic, A., Symeonidis, A., Huls, G., Cermak, J., et al. (2018) · Haematologica · doi:10.3324/haematol.2017.171884 · Cited by 48
Metadata
- Authors
- Hod, E. A., Brittenham, G. M., Billote, G. B., Francis, R. O., Ginzburg, Y. Z., Hendrickson, J. E., Jhang, J., Schwartz, J., Sharma, S., Sheth, S., Sireci, A. N., Stephens, H. L., Stotler, B. A., Wojczyk, B. S., Zimring, J. C., & Spitalnik, S. L.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2011-12-15
- Volume
- 118
- Issue
- 25
- Pages
- 6675-6682
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2126770702
- Cited by
- 297
- References
- 1
- FWCI
- 13.35
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Hod, E. A., Brittenham, G. M., Billote, G. B., Francis, R. O., Ginzburg, Y. Z., Hendrickson, J. E., Jhang, J., Schwartz, J., Sharma, S., Sheth, S., Sireci, A. N., Stephens, H. L., Stotler, B. A., Wojczyk, B. S., Zimring, J. C., & Spitalnik, S. L. (2011). Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non–transferrin-bound iron. Blood. https://doi.org/10.1182/blood-2011-08-371849
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