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Hemogenic endothelium during development and beyond
Open accessAbstract
During embryonic development, multilineage HSCs/progenitor cells are derived from specialized endothelial cells, termed hemogenic endothelium, within the yolk sac, placenta, and aorta. Whether hemogenic endothelial cells contribute to blood cell development at other sites of definitive hematopoiesis, such as in the fetal liver and fetal bone marrow, is not known. Also unknown is whether such cells exist within the vasculature of adult bone marrow and generate hematopoietic stem cells after birth. These issues and their clinical relevance are discussed herein.
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“Inducible lineage tracing of early hemogenic sites with Cdh5-cre, however, does not account for all hematopoietic cells within the embryo”
From Single-Cell Transcriptomics Reveals Early Emergence of Liver Parenchymal and Non-parenchymal Cell Lineages (2020) · cites this paper as Hirschi, 2012
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Self-citationLyndina, Y., Sikora, V., Hyriavenko, N., Lyndіn, M., & Romaniuk, A. M. (2019) · Reports of Vinnytsia National Medical University · doi:10.31393/reports-vnmedical-2019-23(1)-09 · Cited by 1
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Identification of Arterial Phenotype in Endothelial Cells Derived From Human Pluripotent Stem Cells
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Metadata
- Authors
- Hirschi, K. K.
- Affiliations
- Yale University (US)
- Corresponding author
- Hirschi, Karen K.
- ORCID
- Hirschi, Karen K.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2012-05-24
- Volume
- 119
- Issue
- 21
- Pages
- 4823-4827
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC3367889
- OpenAlex
- W2030242990
- Cited by
- 124
- References
- 52
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 8 · 2021: 3 · 2020: 8 · 2019: 8 · 2018: 8 · 2017: 16 · 2016: 13 · 2015: 16 · 2014: 15 · 2013: 12 · 2012: 3
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- hemogenic endothelium, hematopoietic stem cells, definitive hematopoiesis, yolk sac, placenta, aorta, fetal liver, fetal bone marrow, hematopoietic progenitor cells, embryonic development
- MeSH terms
- Adult, Animals, Hematopoiesis, Hematopoietic Stem Cells, Humans, Models, Biological, Embryonic Development, Growth and Development, Mice, Hemangioblasts
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