Autonomous murine T-cell progenitor production in the extra-embryonic yolk sac before HSC emergence
Open accessAbstract
The extra-embryonic yolk sac (YS) is the first hematopoietic site in the mouse embryo and is thought to generate only primitive erythroid and myeloerythroid progenitor cells before definitive HSC emergence within the embryo on E10.5. Here, we have shown the existence of T cell–restricted progenitors in the E9.5 YS that directly engraft in recipient immunodeficient mice. T-cell progenitors were also produced in vitro from both YS and para-aortic splanchnopleura hemogenic endothelial cells, and these T-cell progenitors repopulated the thymus and differentiated into mature T-cell subsets in vivo on transplantation. Our data confirm that the YS produces T-lineage–restricted progenitors that are available to colonize the thymus and provide new insight into the YS as a definitive hematopoietic site in the mouse embryo.
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The first wave of T cell development in the fetus is now thought to arise from these non-stem-cell precursors in the yolk sac.
“The first wave of T cell development in the fetus is now thought to arise from these non-stem-cell precursors in the yolk sac (132, 133).”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [132]
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References 48 · Cited by 178
- Authors
- Yoshimoto, M., Porayette, P., Glosson, N. L., Conway, S. J., Carlesso, N., Cardoso, A. A., Kaplan, M. H., & Yoder, M. C.
- Affiliations
- Department of Pediatrics, Herman B Wells Center for Pediatric Research,
- Indiana University Melvin and Bren Simon Comprehensive Cancer Center (US)
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2012-06-14
- Volume
- 119
- Issue
- 24
- Pages
- 5706-5714
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC3382930
- OpenAlex
- W1970141199
- Cited by
- 178
- References
- 48
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 13 · 2023: 22 · 2022: 8 · 2021: 16 · 2020: 13 · 2019: 17 · 2018: 14 · 2017: 12 · 2016: 10 · 2015: 12 · 2014: 11 · 2013: 11 · 2012: 3
- FWCI
- 7.89
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI080759, R01AI057459)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK090948)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- T cell progenitors, hematopoiesis, hemogenic endothelium, thymus colonization, T cell differentiation, hematopoietic stem cells, mouse embryo, engraftment
- MeSH terms
- Animals, Animals, Newborn, Aorta, Cell Differentiation, Hematopoietic Stem Cells, Mice, Inbred C57BL, Spleen, T-Lymphocytes, Thymus Gland, Yolk Sac, T-Lymphocyte Subsets, Hematopoietic Stem Cell Transplantation, Endothelial Cells, Mice
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