The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Management of bleeding in acquired hemophilia A: results from the European Acquired Haemophilia (EACH2) Registry
Open accessAbstract
Acquired hemophilia A is a rare bleeding disorder caused by autoantibodies to coagulation FVIII. Bleeding episodes at presentation are spontaneous and severe in most cases. Optimal hemostatic therapy is controversial, and available data are from observational and retrospective studies only. The EACH2 registry, a multicenter, pan-European, Web-based database, reports current patient management. The aim was to assess the control of first bleeding episodes treated with a bypassing agent (rFVIIa or aPCC), FVIII, or DDAVP among 501 registered patients. Of 482 patients with one or more bleeding episodes, 144 (30%) received no treatment for bleeding; 31 were treated with symptomatic therapy only. Among 307 patients treated with a first-line hemostatic agent, 174 (56.7%) received rFVIIa, 63 (20.5%) aPCC, 56 (18.2%) FVIII, and 14 (4.6%) DDAVP. Bleeding was controlled in 269 of 338 (79.6%) patients treated with a first-line hemostatic agent or ancillary therapy alone. Propensity score matching was applied to allow unbiased comparison between treatment groups. Bleeding control was significantly higher in patients treated with bypassing agents versus FVIII/DDAVP (93.3% vs 68.3%; P = .003). Bleeding control was similar between rFVIIa and aPCC (93.0%; P = 1). Thrombotic events were reported in 3.6% of treated patients with a similar incidence between rFVIIa (2.9%) and aPCC (4.8%).
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Cites
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International Recommendations on the Diagnosis and Treatment of Acquired Hemophilia A
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Self-citationDiagnosis and management of acquired coagulation inhibitors: a guideline from UKHCDO
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Laboratory Diagnosis of Acquired Hemophilia A: Limitations, Consequences, and Challenges
Werwitzke, S., Scharf, R., & Tiede, A. (2014) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0034-1390004 · Cited by 114
Metadata
- Authors
- Baudo, F., Collins, P., Huth-Kühne, A., Lévesque, H., Marco, P., Nemes, L., Pellegrini, F., Tengborn, L., & Knoebl, P.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2012-07-05
- Volume
- 120
- Issue
- 1
- Pages
- 39-46
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2001205289
- Cited by
- 386
- References
- 25
- FWCI
- 16.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Baudo, F., Collins, P., Huth-Kühne, A., Lévesque, H., Marco, P., Nemes, L., Pellegrini, F., Tengborn, L., & Knoebl, P. (2012). Management of bleeding in acquired hemophilia A: results from the European Acquired Haemophilia (EACH2) Registry. Blood. https://doi.org/10.1182/blood-2012-02-408930
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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