Cited by 129Cancer-related Molecular PathwaysHematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

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The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans

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Pant, Vinod, Quintás-Cardama, Alfonso, Lozano, Guillermina·2012·Blood

DOI 10.1182/blood-2012-05-356014PMC PMC3537308

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Abstract

Aberrations in the p53 tumor suppressor pathway are associated with hematologic malignancies. p53-dependent cell cycle control, senescence, and apoptosis functions are actively involved in maintaining hematopoietic homeostasis under normal and stress conditions. Whereas loss of p53 function promotes leukemia and lymphoma development in humans and mice, increased p53 activity inhibits hematopoietic stem cell function and results in myelodysplasia. Thus, exquisite regulation of p53 activity is critical for homeostasis. Most of our understanding of p53 function in hematopoiesis is derived from genetically engineered mice. Here we summarize some of these models, the various mechanisms that disrupt the regulation of p53 activity, and their relevance to human disease.

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Authors: Pant, V., Quintás-Cardama, A., & Lozano, G.
Affiliations: Departments of Genetics and
Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
ORCID: Pant, Vinod
Lozano, Guillermina
Venue: Blood
Publisher: American Society of Hematology
Published: 2012-12-20
Volume: 120
Issue: 26
Pages: 5118-5127
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2012-05-356014
PMC: PMC3537308
OpenAlex: W1983610544
Cited by: 129
References: 147
Citations by year: 2026: 3 · 2025: 11 · 2024: 10 · 2023: 11 · 2022: 5 · 2021: 13 · 2020: 11 · 2019: 7 · 2018: 10 · 2017: 10 · 2016: 8 · 2015: 13 · 2014: 8 · 2013: 9
FWCI: 0.99
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Blood (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Cancer Institute (CA47296, R01CA047296, P30CA016672)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
Keywords: p53, hematopoiesis, hematologic malignancies, hematopoietic stem cells, myelodysplastic syndrome, leukemia, lymphoma, cell cycle regulation, senescence, apoptosis, hematopoietic homeostasis, genetically engineered mouse models, p53 regulation
MeSH terms: Animals, Hematologic Diseases, Hematopoiesis, Humans, Learning, Models, Biological, Signal Transduction, Tumor Suppressor Protein p53, Models, Animal, Mice

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The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans

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