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The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment
Abstract
Key Points: The Rac effector p21-activated kinase (Pak) regulates hematopoietic engraftment. Pak integrates cytoskeletal changes and proliferation pathways.
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“PAKs are serine/threonine kinases which act as major downstream effectors of the Rho-GTPases family19–21.”
From Gadd45g insufficiency drives the pathogenesis of myeloproliferative neoplasms (2024) · cites this paper as [21]
Citations
Cites
Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization
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Self-citationChae, H.-D., Lee, K. E., Williams, D. A., & Gu, Y. (2008) · Blood · doi:10.1182/blood-2007-06-093237 · Cited by 81
Self-citation
Research works printed but not linked: 34
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Cited by
Gadd45g insufficiency drives the pathogenesis of myeloproliferative neoplasms
Zhang, P., You, N., Ding, Y., Zhu, W., Wang, N., Xie, Y., Huang, W., Ren, Q., Qin, T., Fu, R., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47297-2 · Cited by 11
Metadata
- Authors
- Dorrance, A. M., De Vita, S., Radu, M., Reddy, P. N. G., McGuinness, M. K., Harris, C. E., Mathieu, R., Lane, S. W., Kosoff, R., Milsom, M. D., Chernoff, J., & Williams, D. A.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2013-03-28
- Volume
- 121
- Issue
- 13
- Pages
- 2474-2482
- ISSN
- 0006-4971
- 1528-0020
- Cited by
- 33
- References
- 2
- Language
- en
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