Thrombospondin-1 modulates VEGF signaling via CD36 by recruiting SHP-1 to VEGFR2 complex in microvascular endothelial cells
Open accessAbstract
Key Points: TSP-1 binding to CD36 recruits SHP-1 to CD36-VEGFR2 complex in microvascular endothelial cells. SHP-1 recruitment to CD36-VEGFR2 complex dephosphorylates VEGFR2 and inhibits angiogenesis.
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THBS1 from senescent fibroblasts was predicted to target macrophages, T/NK cells, and endothelial cells through CD47 and CD36.
“THBS1 from senescent fibroblasts was predicted to target macrophages, T/NK cells, and endothelial cells through CD47 and CD36, implicating THBS1 as a central mediator of immune modulation and anti-angiogenic signaling in senescent niches (Figure 6F).64,65,66”
From Cellular senescence in human liver under normal aging and cancer (2026) · cites this paper as [66]
THBS1 is a central mediator of immune modulation and anti-angiogenic signaling in senescent niches.
“THBS1 from senescent fibroblasts was predicted to target macrophages, T/NK cells, and endothelial cells through CD47 and CD36, implicating THBS1 as a central mediator of immune modulation and anti-angiogenic signaling in senescent niches (Figure 6F).64,65,66”
From Cellular senescence in human liver under normal aging and cancer (2026) · cites this paper as [66]
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References 44 · Cited by 167
- Authors
- Chu, L.-Y., Ramakrishnan, D. P., & Silverstein, R. L.
- Affiliations
- Cleveland Clinic (US)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2013-09-05
- Volume
- 122
- Issue
- 10
- Pages
- 1822-1832
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC3765061
- OpenAlex
- W2089645605
- Cited by
- 167
- References
- 44
- Citations by year
- 2026: 14 · 2025: 13 · 2024: 14 · 2023: 8 · 2022: 18 · 2021: 13 · 2020: 11 · 2019: 14 · 2018: 13 · 2017: 13 · 2016: 12 · 2015: 10 · 2014: 13 · 2013: 1
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Case Western Reserve University
- National Health Research Institutes
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL085718, HL085718)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Keywords
- thrombospondin-1, CD36, SHP-1, VEGFR2, VEGF signaling, microvascular endothelial cells, receptor tyrosine phosphatase, angiogenesis, endothelial cell migration, tube formation, VEGFR2 phosphorylation
- MeSH terms
- Animals, Cell Movement, Mice, Inbred C57BL, Models, Biological, Phosphorylation, Protein Binding, Signal Transduction, Gene Deletion, Protein Structure, Tertiary, Neovascularization, Physiologic, CD36 Antigens, Thrombospondin 1, Vascular Endothelial Growth Factor Receptor-2, Vascular Endothelial Growth Factor A, Endothelial Cells, Mice, Protein Tyrosine Phosphatase, Non-Receptor Type 6, Microvessels
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