The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use
Open accessAbstract
Key Points: GMI-1070 led to statistically insignificant but large reductions in time to resolution of VOC and a significant reduction in opioid use. These results support a role for selectins in VOC and progression to a phase 3 study of GMI-1070 for SCD patients with vaso-occlusion.
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Citations
Cites
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Self-citationThe inherited diseases of hemoglobin are an emerging global health burden
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Cited by
Sorted by citations
Varki, A. (2017) · Glycobiology · doi:10.1093/glycob/cww086 · Cited by 2,635
“The effectiveness of the pan-selectin inhibitor GMI-1070 in reducing selectin-mediated cell adhesion and abrogating crisis shows much promise in early clinical trials (922, 929).”
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Neutrophils as emerging therapeutic targets
Németh, T., Sperandio, M., & Mócsai, A. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0054-z · Cited by 676
Metadata
- Authors
- Telen, M. J., Wun, T., McCavit, T. L., De Castro, L. M., Krishnamurti, L., Lanzkron, S., Hsu, L. L., Smith, W. R., Rhee, S., Magnani, J. L., & Thackray, H.
- Affiliations
- Duke University (US)
- VA Northern California Health Care System (US)
- The University of Texas Southwestern Medical Center (US)
- Department of Medicine, Division of Hematology and Oncology, University of Pittsburgh, Pittsburgh, PA;
- Emory University (US)
- Johns Hopkins University (US)
- University of Illinois Chicago (US)
- Virginia Commonwealth University (US)
- Rho (United States) (US)
- GlycoMimetics (United States) (US)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2015-04-23
- Volume
- 125
- Issue
- 17
- Pages
- 2656-2664
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC4408290
- OpenAlex
- W2077716817
- Cited by
- 211
- References
- 34
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 10 · 2023: 8 · 2022: 10 · 2021: 20 · 2020: 24 · 2019: 36 · 2018: 27 · 2017: 24 · 2016: 24 · 2015: 13
- FWCI
- 16.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- University of California
- Children's Hospital of Philadelphia
- University of Miami
- Emory University
- Cincinnati Children's Hospital Medical Center
- Harvard University
- Johns Hopkins University
- University of Cincinnati
- Virginia Commonwealth University
- Children's National Hospital
- Hospital for Sick Children
- University of Illinois at Urbana-Champaign
- Leonard M. Miller School of Medicine
- University of Colorado Denver
- Children's Hospital of Pittsburgh
- Topics
- Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
- Health Sciences › Medicine › Hematology › Blood groups and transfusion
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Keywords
- sickle cell disease, vaso-occlusive crisis, selectin inhibitors, cell adhesion, opioid analgesic use, time to resolution, drug safety
- MeSH terms
- Adolescent, Adult, Analgesics, Analgesics, Opioid, Anemia, Sickle Cell, Child, Double-Blind Method, Female, Glycolipids, Humans, Male, Middle Aged, Prospective Studies, Vascular Diseases, Young Adult
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