The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells
Abstract
Key Points: ATRA and ATO affect NPM1 protein levels in AML cells and induce cell growth inhibition and apoptosis. AML cells with mutated NPM1 respond to ATRA/ATO, and this might be exploited therapeutically.
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“shifts in the balance of transcription factors related to hematopoietic differentiation have been implicated in the pathogenesis of leukemia and therapeutic agents affecting that balance are used successfully in the clinic (e.g., all-trans retinoic acid for acute myeloid leukemia). 42”
From RhoH is a negative regulator of eosinophilopoiesis (2016) · cites this paper as [42]
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Citations
Cites
Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia
Patel, J. P., Gönen, M., Figueroa, M. E., Fernandez, H. F., Sun, Z., Racevskis, J., Vlierberghe, P. V., Dolgalev, I., Thomas, S., Aminova, O., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1112304 · Cited by 1,990
Cytoplasmic Nucleophosmin in Acute Myelogenous Leukemia with a Normal Karyotype
Falini, B., Mecucci, C., Tiacci, E., Alcalay, M., Rosati, R., Pasqualucci, L., La Starza, R., Diverio, D., Colombo, E., Santucci, A., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa041974 · Cited by 1,892
Self-citationRetinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia
Lo-Coco, F., Avvisati, G., Vignetti, M., Thiede, C., Orlando, S. M., Iacobelli, S., Ferrara, F., Fazi, P., Cicconi, L., Di Bona, E., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1300874 · Cited by 1,611
Mechanisms of action of arsenic trioxide.
Miller, W. H., Schipper, H. M., Lee, J. S., Singer, J. W., & Waxman, S. (2002) · PubMed · Cited by 956
Falini, B., Nicoletti, I., Martelli, M. F., & Mecucci, C. (2007) · Blood · doi:10.1182/blood-2006-07-012252 · Cited by 565
Self-citationRole of nucleophosmin in embryonic development and tumorigenesis
Grisendi, S., Bernardi, R., Rossi, M., Cheng, K., Khandker, L., Manova, K., & Pandolfi, P. P. (2005) · Nature · doi:10.1038/nature03915 · Cited by 561
PML targeting eradicates quiescent leukaemia-initiating cells
Ito, K., Bernardi, R., Morotti, A., Matsuoka, S., Saglio, G., Ikeda, Y., Rosenblatt, J., Avigan, D. E., Teruya-Feldstein, J., & Pandolfi, P. P. (2008) · Nature · doi:10.1038/nature07016 · Cited by 538
Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin
Garzon, R., Garofalo, M., Martelli, M. P., Briesewitz, R., Wang, L., Fernandez-Cymering, C., Volinia, S., Liu, C., Schnittger, S., Haferlach, T., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800135105 · Cited by 508
Self-citationZhu, J., Koken, M. H. M., Quignon, F., Chelbi-Alix, M. K., Degos, L., Wang, Z. Y., Chen, Z., & de Thé, H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.3978 · Cited by 427
PML induces a novel caspase-independent death process
Quignon, F., De Bels, F., Koken, M., Feunteun, J., Ameisen, J.-C., & de Thé, H. (1998) · Nature Genetics · doi:10.1038/3068 · Cited by 374
Cited by
Differentiation therapy revisited
de Thé, H. (2018) · Nature reviews. Cancer · doi:10.1038/nrc.2017.103 · Cited by 462
RhoH is a negative regulator of eosinophilopoiesis
Stoeckle, C., Geering, B., Yousefi, S., Rožman, S., Andina, N., Benarafa, C., & Simon, H.-U. (2016) · Cell Death & Differentiation · doi:10.1038/cdd.2016.73 · Cited by 24
Metadata
- Authors
- Martelli, M. P., Gionfriddo, I., Mezzasoma, F., Milano, F., Pierangeli, S., Mulas, F., Pacini, R., Tabarrini, A., Pettirossi, V., Rossi, R., Vetro, C., Brunetti, L., Sportoletti, P., Tiacci, E., Di Raimondo, F., & Falini, B.
- Affiliations
- Institute of Hematology, Centro di Ricerca Emato-Oncologico (CREO), University of Perugia, Perugia, Italy; and
- Institute of Hematology, University of Catania, Catania, Italy
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2015-05-28
- Volume
- 125
- Issue
- 22
- Pages
- 3455-3465
- ISSN
- 0006-4971
- 1528-0020
- Cited by
- 139
- References
- 40
- Language
- en
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- CoChat. (2026). Citation check: Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells. https://app.cochat.ai/papers/10.1182/blood-2014-11-611459
- The paper
- Martelli, M. P., Gionfriddo, I., Mezzasoma, F., Milano, F., Pierangeli, S., Mulas, F., Pacini, R., Tabarrini, A., Pettirossi, V., Rossi, R., Vetro, C., Brunetti, L., Sportoletti, P., Tiacci, E., Di Raimondo, F., & Falini, B. (2015). Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells. Blood. https://doi.org/10.1182/blood-2014-11-611459
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
