The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.
Hematopoietic stem cell transplantation for patients with AML in first complete remission
Abstract
Postremission therapy in patients with acute myeloid leukemia (AML) may consist of continuing chemotherapy or transplantation using either autologous or allogeneic stem cells. Patients with favorable subtypes of AML generally receive chemotherapeutic consolidation, although recent studies have also suggested favorable outcome after hematopoietic stem cell transplantation (HSCT). Although allogeneic HSCT (alloHSCT) is considered the preferred type of postremission therapy in poor- and very-poor-risk AML, the place of alloHSCT in intermediate-risk AML is being debated, and autologous HSCT is considered a valuable alternative that may be preferred in patients without minimal residual disease after induction chemotherapy. Here, we review postremission transplantation strategies using either autologous or allogeneic stem cells. Recent developments in the field of alternative donors, including cord blood and haploidentical donors, are highlighted, and we discuss reduced-intensity alloHSCT in older AML recipients who represent the predominant category of patients with AML who have a high risk of relapse in first remission.
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Metadata
- Authors
- Cornelissen, J. J., & Blaise, D.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2016-01-07
- Volume
- 127
- Issue
- 1
- Pages
- 62-70
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2296458069
- Cited by
- 346
- References
- 89
- FWCI
- 17.41
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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