Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice
Open accessAbstract
Key Points: Hyperactivation of the BMP-SMAD pathway blunts EPO-mediated hepcidin inhibition. Lack of BMP-SMAD pathway inhibition by matriptase-2 abrogates the ERFE-mediated hepcidin suppression in response to EPO.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ERFE fails to suppress hepcidin when the BMP pathway is overactive.
“However, ERFE fails to suppress hepcidin when the BMP pathway is overactive.73”
From Iron metabolism and iron disorders revisited in the hepcidin era (2020) · cites this paper as [73]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 40 · Cited by 97
- Authors
- Nai, A., Rubio, A., Campanella, A., Gourbeyre, O., Artuso, I., Bordini, J., Gineste, A., Latour, C., Besson-Fournier, C., Lin, H. Y., Coppin, H., Roth, M.-P., Camaschella, C., Silvestri, L., & Meynard, D.
- Affiliations
- Vita-Salute San Raffaele University (IT)
- Inserm (FR)
- IRCCS Ospedale San Raffaele (IT)
- Institut de Recherche en Santé Digestive, INSERM U1220, Université de Toulouse, Institut National de la Recherche Agronomique, Institut National Polytechnique–École Nationale Vétérinaire de Toulouse, Toulouse, France; and
- Harvard University (US)
- Corresponding author
- Nai, Antonella
- Rubio, Aude
- Silvestri, Laura
- Meynard, Delphine
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2016-05-12
- Volume
- 127
- Issue
- 19
- Pages
- 2327-2336
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC4865590
- OpenAlex
- W2363525505
- Cited by
- 97
- References
- 40
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 9 · 2020: 14 · 2019: 16 · 2018: 14 · 2017: 19 · 2016: 4
- FWCI
- 16.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Cooley's Anemia Foundation
- Massachusetts General Hospital
- Fondation Maladies Rares
- Agence Nationale de la Recherche (ANR-09-GENO-0016)
- Institut National de la Santé et de la Recherche Médicale
- Ministero dell’Istruzione, dell’Università e della Ricerca (PRIN 2010-2011 “, 2010-2011, (PRIN 2010))
- Universidad de Oviedo
- National Institutes of Health (2010-2011, RO1 DK-071837)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK071837)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Physical Sciences › Engineering › Mechanical Engineering › Iron and Steelmaking Processes
- Keywords
- matriptase-2, TMPRSS6, hepcidin, erythropoietin, erythroferrone, BMP/Smad signaling, iron homeostasis, iron-refractory iron deficiency anemia, stress erythropoiesis, compound C, BMP6, serine protease
- MeSH terms
- Animals, Erythropoietin, Liver, Membrane Proteins, Serine Endopeptidases, Signal Transduction, Mice, Knockout, Bone Morphogenetic Proteins, Mice, Smad Proteins, Hepcidins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
