Calreticulin exposure by malignant blasts correlates with robust anticancer immunity and improved clinical outcome in AML patients
Open accessAbstract
Key Points: Malignant cells from patients with AML expose danger signals on the plasma membrane regardless of chemotherapy. Such danger signals correlate with markers of a clinically relevant tumor-specific immune response and with improved disease outcome.
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CALR exposure has positive prognostic value in AML.
“Accordingly, while CALR exposure has positive prognostic value in patients with acute myeloid leukemia (AML) [887]”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [887]
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References 40 · Cited by 135
- Authors
- Fucikova, J., Truxova, I., Hensler, M., Becht, E., Kasikova, L., Moserova, I., Vosahlikova, S., Klouckova, J., Church, S. E., Cremer, I., Kepp, O., Kroemer, G., Galluzzi, L., Salek, C., & Spisek, R.
- Affiliations
- Charles University (CZ)
- Department of Immunology, Charles University, 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic;
- Sotio (Czechia) (CZ)
- INSERM, U1138, Centre de Recherche des Cordeliers, Paris, France;
- Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic;
- Inserm (FR)
- Karolinska University Hospital (SE)
- Institute of Hematology and Blood Transfusion, Prague, Czech Republic; and
- Corresponding author
- Fucikova, Jitka
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2016-12-29
- Volume
- 128
- Issue
- 26
- Pages
- 3113-3124
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC5201098
- OpenAlex
- W2547161910
- Cited by
- 135
- References
- 40
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 16 · 2023: 12 · 2022: 16 · 2021: 12 · 2020: 21 · 2019: 20 · 2018: 13 · 2017: 15
- FWCI
- 15.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Blood (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Keywords
- calreticulin, acute myeloid leukemia, tumor-associated antigens, antitumor immunity, leukemia-associated antigens, peripheral blood T cells, prognostic factors, relapse-free survival, overall survival, HSP70, HSP90
- MeSH terms
- Alarmins, Blast Crisis, Female, Humans, Immunity, Male, Middle Aged, Phenotype, Transcription, Genetic, Leukemia, Myeloid, Acute, Gene Expression Regulation, Leukemic, Multivariate Analysis, Proportional Hazards Models, Treatment Outcome, Cell Death, CD8-Positive T-Lymphocytes, Th1 Cells, HSP70 Heat-Shock Proteins, HSP90 Heat-Shock Proteins, Gene Expression Profiling, Calreticulin
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