The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Biology and relevance of human acute myeloid leukemia stem cells
Open accessAbstract
Evidence of human acute myeloid leukemia stem cells (AML LSCs) was first reported nearly 2 decades ago through the identification of rare subpopulations of engrafting cells in xenotransplantation assays. These AML LSCs were shown to reside at the apex of a cellular hierarchy that initiates and maintains the disease, exhibiting properties of self-renewal, cell cycle quiescence, and chemoresistance. This cancer stem cell model offers an explanation for chemotherapy resistance and disease relapse and implies that approaches to treatment must eradicate LSCs for cure. More recently, a number of studies have both refined and expanded our understanding of LSCs and intrapatient heterogeneity in AML using improved xenotransplant models, genome-scale analyses, and experimental manipulation of primary patient cells. Here, we review these studies with a focus on the immunophenotype, biological properties, epigenetics, genetics, and clinical associations of human AML LSCs and discuss critical questions that need to be addressed in future research.
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Cites
Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
The Cancer Genome Atlas Research Network (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1301689 · Cited by 5,078
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Self-citationTransformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9
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Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
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Cited by
Targeting Cancer Stemness in the Clinic: From Hype to Hope
Saygin, C., Matei, D., Majeti, R., Reizes, O., & Lathia, J. D. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2018.11.017 · Cited by 517
Self-citationMyelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level
Chen, J., Kao, Y.-R., Sun, D., Todorova, T. I., Reynolds, D., Narayanagari, S.-R., Montagna, C., Will, B., Verma, A., & Steidl, U. (2019) · Nature Medicine · doi:10.1038/s41591-018-0267-4 · Cited by 226
TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal
Li, Y., Xue, M., Deng, X., Dong, L., Nguyen, L. X. T., Ren, L., Han, L., Li, C., Xue, J., Zhao, Z., et al. (2023) · Cell Stem Cell · doi:10.1016/j.stem.2023.07.001 · Cited by 110
Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia
McKenzie, M. D., Ghisi, M., Oxley, E. P., Ngo, S., Cimmino, L., Esnault, C., Liu, R., Salmon, J. M., Bell, C. C., Ahmed, N., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.07.001 · Cited by 91
Metadata
- Authors
- Thomas, D., & Majeti, R.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2017-03-23
- Volume
- 129
- Issue
- 12
- Pages
- 1577-1585
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2585283489
- Cited by
- 500
- References
- 17
- FWCI
- 27.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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