The DOI matches its Crossref record; 111 of the 111 references it cites were found in a registry or an index.
The genetics and molecular biology of T-ALL
Open accessAbstract
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy caused by the accumulation of genomic lesions that affect the development of T cells. For many years, it has been established that deregulated expression of transcription factors, impairment of the CDKN2A/2B cell-cycle regulators, and hyperactive NOTCH1 signaling play prominent roles in the pathogenesis of this leukemia. In the past decade, systematic screening of T-ALL genomes by high-resolution copy-number arrays and next-generation sequencing technologies has revealed that T-cell progenitors accumulate additional mutations affecting JAK/STAT signaling, protein translation, and epigenetic control, providing novel attractive targets for therapy. In this review, we provide an update on our knowledge of T-ALL pathogenesis, the opportunities for the introduction of targeted therapy, and the challenges that are still ahead.
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Mutation and cancer: statistical study of retinoblastoma
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Cited by
Arber, D. A., Orazi, A., Hasserjian, R. P., Borowitz, M. J., Calvo, K. R., Kvasnicka, H.-M., Wang, S. A., Bagg, A., Barbui, T., Branford, S., et al. (2022) · Blood · doi:10.1182/blood.2022015850 · Cited by 2,945
USP7 deubiquitinates and stabilizes NOTCH1 in T-cell acute lymphoblastic leukemia
Shan, H., Li, X., Xiao, X., Dai, Y., Huang, J., Song, J., Liu, M., Yang, L., Lei, H., Tong, Y., et al. (2018) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-018-0028-3 · Cited by 66
Glaser, V., Flugel, C., Kath, J., Du, W., Drosdek, V., Franke, C., Stein, M., Pruß, A., Schmueck-Henneresse, M., Volk, H.-D., et al. (2023) · Genome biology · doi:10.1186/s13059-023-02928-7 · Cited by 65
Metadata
- Authors
- Girardi, T., Vicente, C., Cools, J., & De Keersmaecker, K.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2017-03-02
- Volume
- 129
- Issue
- 9
- Pages
- 1113-1123
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2581394992
- Cited by
- 355
- References
- 111
- FWCI
- 28.04
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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