SCL/TAL1: a multifaceted regulator from blood development to disease
Open accessAbstract
Abstract SCL/TAL1 (stem cell leukemia/T-cell acute lymphoblastic leukemia [T-ALL] 1) is an essential transcription factor in normal and malignant hematopoiesis. It is required for specification of the blood program during development, adult hematopoietic stem cell survival and quiescence, and terminal maturation of select blood lineages. Following ectopic expression, SCL contributes to oncogenesis in T-ALL. Remarkably, SCL’s activities are all mediated through nucleation of a core quaternary protein complex (SCL:E-protein:LMO1/2 [LIM domain only 1 or 2]:LDB1 [LIM domain-binding protein 1]) and dynamic recruitment of conserved combinatorial associations of additional regulators in a lineage- and stage-specific context. The finely tuned control of SCL’s regulatory functions (lineage priming, activation, and repression of gene expression programs) provides insight into fundamental developmental and transcriptional mechanisms, and highlights mechanistic parallels between normal and oncogenic processes. Importantly, recent discoveries are paving the way to the development of innovative therapeutic opportunities in SCL+ T-ALL.
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BHLHA15 is involved in immune B cell differentiation and TAL1 is involved in hematopoiesis.
“which have been respectively found to be involved in immune B cell differentiation [58] and hematopoiesis [59].”
From Denisovan introgression has shaped the immune system of present-day Papuans (2022) · cites this paper as [59]
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References 128 · Cited by 135
Part of this paper’s reference list could not be split into single entries.
Research works printed but not linked: 1
- Kataoka H, Hayashi M, Nakagawa R, et al. Etv2/ ER71 induces vascular mesoderm from Flk11 PDGFRa 1 primitive mesoderm. Blood. 2011; 118(26):6975-6986.
- Authors
- Porcher, C., Chagraoui, H., & Kristiansen, M. S.
- Affiliations
- John Radcliffe Hospital (GB)
- Medical Research Council Molecular Haematology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
- ORCID
- Porcher, Catherine
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2017-04-13
- Volume
- 129
- Issue
- 15
- Pages
- 2051-2060
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2587699608
- Cited by
- 135
- References
- 128
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 18 · 2023: 12 · 2022: 12 · 2021: 18 · 2020: 13 · 2019: 18 · 2018: 15 · 2017: 6
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Directorate for Biological Sciences
- Medical Research Council (MC_UU_00016/9)
- Biotechnology and Biological Sciences Research Council
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- SCL/TAL1, transcription factors, hematopoiesis, T-cell acute lymphoblastic leukemia, hematopoietic stem cells, hematopoietic lineage specification, E protein, LMO1, LMO2, LDB1, carcinogenesis, gene expression regulation, therapeutic target
- MeSH terms
- T-Cell Acute Lymphocytic Leukemia Protein 1, Animals, DNA-Binding Proteins, Hematopoiesis, Hematopoietic Stem Cells, Humans, Proto-Oncogene Proteins, Transcription Factors, Gene Expression Regulation, Leukemic, Adaptor Proteins, Signal Transducing, Basic Helix-Loop-Helix Proteins, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, LIM Domain Proteins
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