The impact of aging on primate hematopoiesis as interrogated by clonal tracking
Open accessAbstract
Key Points: Genetic barcoding of HSPCs in aged macaques reveals impaired long-term clonal output from multipotent HSPCs. Aged macaques showed prolonged contributions from lineage-biased HSPCs and late clonal expansions.
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While clonal expansion during normal ageing has not yet been observed in mice, it has been reported in mouse models for disease and in physiologically aged macaques.
“While clonal expansion during normal ageing has not yet been observed in mice, it has been reported in mouse models for disease61 and in physiologically aged macaques62.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [62]
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References 43 · Cited by 47
Research works printed but not linked: 1
- [27]Koelle SJ, Espinoza DA, Wu C, et al. Quantitative stability of hematopoietic stem and progenitor cell clonal output in rhesus macaques receiving transplants. Blood. 2017;129(11):1448-1457. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Authors
- Yu, K.-R., Espinoza, D. A., Wu, C., Truitt, L., Shin, T.-H., Chen, S., Fan, X., Yabe, I. M., Panch, S., Hong, S. G., Koelle, S., Lu, R., Bonifacino, A., Krouse, A., Metzger, M., Donahue, R. E., & Dunbar, C. E.
- Affiliations
- National Institutes of Health (US)
- University of Southern California (US)
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2018-03-15
- Volume
- 131
- Issue
- 11
- Pages
- 1195-1205
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC5855019
- OpenAlex
- W2781938049
- Cited by
- 47
- References
- 43
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 9 · 2021: 5 · 2020: 9 · 2019: 10 · 2018: 3
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Blood disorders and treatments
- Keywords
- hematopoietic aging, hematopoietic stem and progenitor cells, clonal tracking, macaque, autologous transplantation
- MeSH terms
- Aging, Animals, Hematopoiesis, Hematopoietic Stem Cells, Macaca, Hematopoietic Stem Cell Transplantation, Cell Tracking, Autografts
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