The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Fostamatinib for the treatment of chronic immune thrombocytopenia
Open accessAbstract
Fostamatinib is a spleen tyrosine kinase inhibitor recently approved for the treatment of chronic immune thrombocytopenia (ITP) in patients without adequate response to at least 1 prior line of therapy. This article reviews fostmatinib’s mechanism of action and its clinical safety and efficacy in 2 industry-sponsored multicenter phase 3 randomized controlled trials in North America, Australia, and Europe (FIT1 and FIT2). Cost comparisons are discussed as well as the role of fostamatinib in relation to other options for chronic ITP.
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“It is a tyrosine kinase inhibitor medication approved for the treatment of chronic immune thrombocytopenia32.”
From ASGARD is a single-cell guided pipeline to aid repurposing of drugs (2023) · cites this paper as [32]
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Rodeghiero, F., Stasi, R., Gernsheimer, T., Michel, M., Provan, D., Arnold, D. M., Bussel, J. B., Cines, D. B., Chong, B. H., Cooper, N., et al. (2008) · Blood · doi:10.1182/blood-2008-07-162503 · Cited by 2,699
Neunert, C. E., Lim, W., Crowther, M. A., Cohen, A. R., Solberg, L. A., & Crowther, M. A. (2011) · Blood · doi:10.1182/blood-2010-08-302984 · Cited by 1,853
Kojouri, K., Vesely, S. K., Terrell, D. R., et al. (2004) · Blood · doi:10.1182/blood-2004-03-1168 · Cited by 653
Arnold, D. M., Dentali, F., Crowther, M. A., Meyer, R. M., Cook, R. J., Sigouin, C. S., Fraser, G. A. M., Lim, W., & Kelton, J. G. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-1-200701020-00006 · Cited by 551
Braselmann, S., Taylor, V., Zhao, H., Wang, S., Sylvain, C., Baluom, M., Qu, K., Herlaar, E., Lau, A., Young, C., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.109058 · Cited by 519
An Oral Spleen Tyrosine Kinase (Syk) Inhibitor for Rheumatoid Arthritis
Weinblatt, M. E., Kavanaugh, A., Genovese, M. C., Musser, T. K., Grossbard, E. B., & Magilavy, D. B. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1000500 · Cited by 386
Bussel, J. B., Arnold, D. M., Grossbard, E., Mayer, J., Treliński, J., Homenda, W., Hellmann, A., Windyga, J., Sivcheva, L., Khalafallah, A. A., et al. (2018) · American Journal of Hematology · doi:10.1002/ajh.25125 · Cited by 378
Patel, V., Mahévas, M., Lee, S. Y., et al. (2012) · Blood · doi:10.1182/blood-2011-11-393975 · Cited by 349
Kristinsson, S. Y., Gridley, G., Hoover, R. N., Check, D. P., & Landgren, O. (2013) · Haematologica · doi:10.3324/haematol.2013.092460 · Cited by 347
Saleh, M. N., Bussel, J. B., Cheng, G. Y.-M., et al. (2012) · Blood · doi:10.1182/blood-2012-04-425512 · Cited by 338
Cited by
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ASGARD is a single-cell guided pipeline to aid repurposing of drugs
He, B., Xiao, Y., Liang, H., Huang, Q., Du, Y., Li, Y., Garmire, D., Sun, D., & Garmire, L. X. (2023) · Nature Communications · doi:10.1038/s41467-023-36637-3 · Cited by 57
Metadata
- Authors
- Connell, N. T., & Berliner, N.
- Affiliations
- Brigham and Women's Hospital (US)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2019-05-09
- Volume
- 133
- Issue
- 19
- Pages
- 2027-2030
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2915813634
- Cited by
- 108
- References
- 29
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 25 · 2023: 16 · 2022: 16 · 2021: 16 · 2020: 7 · 2019: 3
- FWCI
- 7.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Health Sciences › Medicine › Hematology › Blood groups and transfusion
- Health Sciences › Medicine › Hematology › Heparin-Induced Thrombocytopenia and Thrombosis
- Keywords
- fostamatinib, chronic ITP, spleen tyrosine kinase inhibitor, mechanism of action, clinical efficacy, drug safety, cost comparison
- MeSH terms
- Aminopyridines, Humans, Morpholines, Oxazines, Pyridines, Pyrimidines, Purpura, Thrombocytopenic, Idiopathic, Clinical Trials, Phase III as Topic, Protein Kinase Inhibitors
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- Connell, N. T., & Berliner, N. (2019). Fostamatinib for the treatment of chronic immune thrombocytopenia. Blood. https://doi.org/10.1182/blood-2018-11-852491
