Strong Association between Cancer Gene Variants at Diagnosis, Especially ASXL1, and Emergence of Kinase Domain Mutation-Driven Resistance in CML Patients Despite Frontline Treatment with More Potent BCR::ABL1 Inhibitors

Shanmuganathan, Naranie; Wadham, Carol; Yeung, David T; Shahrin, Nur Hezrin; Fernandes, Adelina; Maqsood, Muneeza; Kok, Chung Hoow; Saunders, Verity A; Pagani, Ilaria Stefania; Kenyon, Rosalie; Lin, Ming; Ross, David M; Hughes, Timothy P; Branford, Susan

doi:10.1182/blood-2024-199899

Strong Association between Cancer Gene Variants at Diagnosis, Especially ASXL1, and Emergence of Kinase Domain Mutation-Driven Resistance in CML Patients Despite Frontline Treatment with More Potent BCR::ABL1 Inhibitors

Background We previously demonstrated that additional genetic abnormalities (AGAs) detected at diagnosis had a negative impact on failure-free survival (FFS, as defined by ELN 2020) and molecular response for 200 frontline imatinib-treated patients (pts), despite proactive treatment intervention.…