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The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

CHIP and hips: clonal hematopoiesis is common in patients undergoing hip arthroplasty and is associated with autoimmune disease

Hecker, Judith S., Hartmann, Luise, Rivière, Jennifer, Buck, Michèle C., van der Garde, Mark, Rothenberg-Thurley, Maja, Fischer, Luise, Winter, Susann, Ksienzyk, Bianka, Ziemann, Frank, Solovey, Maria, Rauner, Martina, Tsourdi, Elena, Sockel, Katja, Schneider, Marie, Kubasch, Anne S., Nolde, Martin, Hausmann, Dominikus, Paulus, Alexander C., Lützner, Jörg, Roth, Andreas, Bassermann, Florian, Spiekermann, Karsten, Marr, Carsten, Hofbauer, Lorenz C., Platzbecker, Uwe, Metzeler, Klaus H., Götze, Katharina S.·2021·Blood
DOI 10.1182/blood.2020010163
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Abstract

Clonal hematopoiesis (CH) is an age-related condition predisposing to blood cancer and cardiovascular disease (CVD). Murine models demonstrate CH-mediated altered immune function and proinflammation. Low-grade inflammation has been implicated in the pathogenesis of osteoarthritis (OA), the main indication for total hip arthroplasty (THA). THA-derived hip bones serve as a major source of healthy hematopoietic cells in experimental hematology. We prospectively investigated frequency and clinical associations of CH in 200 patients without known hematologic disease who were undergoing THA. Prevalence of CH was 50%, including 77 patients with CH of indeterminate potential (CHIP, defined as somatic variant allele frequencies [VAFs] ≥2%), and 23 patients harboring CH with lower mutation burden (VAF, 1% to 2%). Most commonly mutated genes were DNMT3A (29.5%), TET2 (15.0%), and ASXL1 (3.5%). CHIP is significantly associated with lower hemoglobin, higher mean corpuscular volume, previous or present malignant disease, and CVD. Strikingly, we observed a previously unreported association of CHIP with autoimmune diseases (AIDs; multivariable adjusted odds ratio, 6.6; 95% confidence interval, 1.7-30; P = .0081). These findings underscore the association between CH and inflammatory diseases. Our results have considerable relevance for managing patients with OA and AIDs or mild anemia and question the use of hip bone–derived cells as healthy experimental controls.

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Research works printed but not linked: 16

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  2. Midic, 2020, Prevalence and dynamics of clonal hematopoiesis caused by leukemia-associated mutations in elderly individuals without hematologic disorders, Leukemia., 34, 2198, 10.1038/s41375-020-0869-y · DOI
  3. Hartmann, 2019, Clonal hematopoiesis and preleukemia-Genetics, biology, and clinical implications, Genes Chromosomes Cancer., 58, 828, 10.1002/gcc.22756 · DOI
  4. Xie, 2014, Age-related mutations associated with clonal hematopoietic expansion and malignancies, Nat Med., 20, 1472, 10.1038/nm.3733 · DOI · Paper page
  5. Sano, 2018, Tet2-mediated clonal hematopoiesis accelerates heart failure through a mechanism involving the IL-1β/NLRP3 inflammasome, J Am Coll Cardiol., 71, 875, 10.1016/j.jacc.2017.12.037 · DOI · Paper page
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  7. Robinson, 2016, Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis, Nat Rev Rheumatol., 12, 580, 10.1038/nrrheum.2016.136 · DOI · Paper page
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Cited by

Metadata

Authors
Hecker, J. S., Hartmann, L., Rivière, J., Buck, M. C., van der Garde, M., Rothenberg-Thurley, M., Fischer, L., Winter, S., Ksienzyk, B., Ziemann, F., Solovey, M., Rauner, M., Tsourdi, E., Sockel, K., Schneider, M., Kubasch, A. S., Nolde, M., Hausmann, D., Paulus, A. C., Lützner, J., Roth, A., Bassermann, F., Spiekermann, K., Marr, C., Hofbauer, L. C., Platzbecker, U., Metzeler, K. H., & Götze, K. S.
Affiliations
  • Department of Medicine III, Klinikum Rechts der Isar, Technical University of Munich (TUM), Munich, Germany;
  • German Cancer Consortium, CHOICE Consortium, partner sites Munich/Dresden, Germany;
  • Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital (LMU), Munich, Germany;
  • Orthopedic Center Bogenhausen, Munich, Germany;
  • Department of Orthopedic Surgery, LMU, Munich, Germany;
  • Department of Orthopedic Surgery, TUD, Dresden, Germany;
  • Department of Orthopedic Surgery, UHL, Leipzig, Germany;
  • Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
ORCID
Venue
Blood
Publisher
American Society of Hematology
Published
2021-11-04
Volume
138
Issue
18
Pages
1727-1732
ISSN
  • 0006-4971
  • 1528-0020
DOI
10.1182/blood.2020010163
Cited by
105
References
9
Language
en

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