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Increased incidence of hematologic malignancies in SCD after HCT in adults with graft failure and mixed chimerism

Lawal, Rialnat A., Mukherjee, Devdeep, Limerick, Emily M., Coles, Wynona, Hsieh, Matthew M., Dillon, Laura W., Hourigan, Christopher S., Fitzhugh, Courtney D.·2022·Blood
DOI 10.1182/blood.2022017960
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Abstract

Lawal et al report on a 45-fold increase in secondary hematologic malignancy in 120 patients following hematopoietic stem cell transplantation (HSCT) for sickle cell disease (SCD), comparable to what has been reported following gene therapy. Notably, the cohort is enriched for older patients and for haploidentical transplant recipients with mixed chimerism following HSCT. These data further support the idea that pre-existing premalignant myeloid clones undergo clonal selection in the setting of nonmyeloablative HSCT and contribute to secondary malignancy.

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Research works printed but not linked: 22

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Metadata

Authors
Lawal, R. A., Mukherjee, D., Limerick, E. M., Coles, W., Hsieh, M. M., Dillon, L. W., Hourigan, C. S., & Fitzhugh, C. D.
Venue
Blood
Publisher
American Society of Hematology
Published
2022-12-08
Volume
140
Issue
23
Pages
2514-2518
ISSN
  • 0006-4971
  • 1528-0020
DOI
10.1182/blood.2022017960
Cited by
49
References
1
Language
en

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CoChat. (2026). Citation check: Increased incidence of hematologic malignancies in SCD after HCT in adults with graft failure and mixed chimerism. https://app.cochat.ai/papers/10.1182/blood.2022017960
The paper
Lawal, R. A., Mukherjee, D., Limerick, E. M., Coles, W., Hsieh, M. M., Dillon, L. W., Hourigan, C. S., & Fitzhugh, C. D. (2022). Increased incidence of hematologic malignancies in SCD after HCT in adults with graft failure and mixed chimerism. Blood. https://doi.org/10.1182/blood.2022017960