The DOI matches its Crossref record.
Clinical staging of chronic lymphocytic leukemia
Abstract
A method of clinical staging of chronic lymphocytic leukemia (CLL) has been proposed which is based on the concept that CLL is a disease of progressive accumulation of nonfunctioning lymphocytes: stage O, bone marrow and blood lymphocytosis only; stage 1, lymphocytosis with enlarged nodes; stage II, lymphocytosis with enlarged spleen or liver or both; stage III, lymphocytosis with anemia; and stage IV:lymphocytosis with thrombocytopenia. Analysis of 125 patients. in the present series showed the following median survival times (in months) from diagnosis: stage 0, is greater than 150; stage I 101; stage II, 71; stage III, 19; stage IV, 19, The median survival for the entire series was 71 mo. The prognostic significance of the stage remained even after adjustment was made for age and sex. However, both sex and age were shown to be poor predictors of survival after adjustment for stage. The method of staging proved to be a reliable predictor of survival whether used at diagnosis or during the course of the disease. The proposed staging system was an equally accurate indicator for survival when applied to two other previously published studies of large series of patients.
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Citations
Cited by
Chiorazzi, N., Rai, K. R., & Ferrarini, M. (2005) · New England Journal of Medicine · doi:10.1056/nejmra041720 · Cited by 1,296
Self-citationCrespo, M., Bosch, F., Villamor, N., Bellosillo, B., Colomer, D., Rozman, M., Marcé, S., López-Guillermo, A., Campo, E., & Montserrat, E. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa023143 · Cited by 1,055
Maddocks, K. J., Ruppert, A. S., Lozanski, G., Heerema, N. A., Zhao, W., Abruzzo, L., Lozanski, A., Davis, M., Gordon, A., Smith, L. L., et al. (2015) · JAMA Oncology · doi:10.1001/jamaoncol.2014.218 · Cited by 584
CLASSIFICATION OF NON-HODGKIN'S LYMPHOMAS
Bennett, M., Farrer-Brown, G., Henry, K., Jelliffe, A. M., Gerard-Marchant, R., Hamlin, I., Lennert, K., Rilke, F., Stansfeld, A. G., & Van Unnik, J. A. M. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91786-3 · Cited by 555
Byrd, J. C., Murphy, T., Howard, R. S., Lucas, M. S., Goodrich, A., Park, K., Pearson, M., Waselenko, J. K., Ling, G., Grever, M. R., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.8.2153 · Cited by 508
Metadata
- Authors
- Rai, K., Sawitsky, A., Cronkite, E., Chanana, A., Levy, R., & Pasternack, B.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1975-08-01
- Volume
- 46
- Issue
- 2
- Pages
- 219-234
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W154103547
- Cited by
- 2,784
- References
- 0
- FWCI
- 18.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Clinical staging of chronic lymphocytic leukemia. https://app.cochat.ai/papers/10.1182/blood.v46.2.219.219
- The paper
- Rai, K., Sawitsky, A., Cronkite, E., Chanana, A., Levy, R., & Pasternack, B. (1975). Clinical staging of chronic lymphocytic leukemia. Blood. https://doi.org/10.1182/blood.v46.2.219.219
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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