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Severe aplastic anemia: a prospective study of the effect of early marrow transplantation on acute mortality
Open accessAbstract
A prospective randomized trial of therapy for severe aplastic anemia was designed to compare early bone marrow transplantation with conventional treatments. All patients with a sibling matched at the major histocompatibility region were transplanted. Transplantation was performed with 17–100 (median 33) days of original diagnosis. Conventional treatments included transfusion support with or without androgens. Twenty-four of 36 patients intered on the transplant arm are alive after 4–20 (median 9) mo with full marrow reconstitution. Only two are limited by chronic graft-versus-host disease. In contrast only 12 of 31 conventionally treated patients are alive. Six of these survivors have improved, five incompletely. The 19 nontransplant deaths have occurred within 1–11 (median 3) mo of diagnosis. Compared to nontransplant regimens, early transplantation more effectively restores normal marrow function and decreases the acute mortality of severe marrow aplasia (p = 0.006). Pending longer follow-up, early marrow transplantation appears to be the most effective available treatment for severe aplastic anemia.
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Citations
Cited by
Camitta, B., Thomas, E., Nathan, D., Gale, R., Kopecky, K., Rappeport, J., Santos, G., Gordon-Smith, E., & Storb, R. (1979) · Blood · doi:10.1182/blood.v53.3.504.504 · Cited by 422
Self-citationZoumbos, N. C., Gascon, P., Djeu, J. Y., & Young, N. S. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.1.188 · Cited by 330
Sugimori, C., Chuhjo, T., Feng, X., Yamazaki, H., Takami, A., Teramura, M., Mizoguchi, H., Omine, M., & Nakao, S. (2006) · Blood · doi:10.1182/blood-2005-06-2485 · Cited by 301
Telomere length is associated with disease severity and declines with age in dyskeratosis congenita
Alter, B. P., Rosenberg, P. S., Giri, N., Baerlocher, G. M., Lansdorp, P. M., & Savage, S. A. (2012) · Haematologica · doi:10.3324/haematol.2011.055269 · Cited by 238
Telomere length in leukocyte subpopulations of patients with aplastic anemia
Brümmendorf, T. H., Maciejewski, J. P., Mak, J., Young, N. S., & Lansdorp, P. M. (2001) · Blood · doi:10.1182/blood.v97.4.895 · Cited by 233
Metadata
- Authors
- Camitta, B., Thomas, E., Nathan, D., Santos, G., Gordon-Smith, E., Gale, R., Rappeport, J., & Storb, R.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1976-07-01
- Volume
- 48
- Issue
- 1
- Pages
- 63-70
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W196567407
- Cited by
- 568
- References
- 0
- FWCI
- 17.74
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Camitta, B., Thomas, E., Nathan, D., Santos, G., Gordon-Smith, E., Gale, R., Rappeport, J., & Storb, R. (1976). Severe aplastic anemia: a prospective study of the effect of early marrow transplantation on acute mortality. Blood. https://doi.org/10.1182/blood.v48.1.63.63
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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