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STUDIES ON THE MECHANISM OF ERYTHROPOIETIC STIMULATION IN PARABIOTIC RATS DURING HYPOXIA
Abstract
Chronic hypoxemia was induced in one partner of a pair of parabiotic rats by exposure to defined gas mixtures with low oxygen content. The other partner of the pair was kept in normal atmosphere throughout the experiment and showed normal values of the oxygen saturation of the blood. The erythropoiesis, estimated by the percentage of nucleated red cells in the bone marrow, showed a statistically significant stimulation in both animals. It is, therefore, concluded that under these experimental conditions, the stimulus is not the partial pressure of oxygen in the bone marrow directly but a humoral factor elicited by the hypoxemia in the one partner and transferred to the other one.
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Citations
Cited by
Erythropoietin: Physiology and Pharmacology Update
Fisher, J. W. (2003) · Experimental Biology and Medicine · doi:10.1177/153537020322800101 · Cited by 708
Sleep in Chronic Obstructive Lung Disease
Flenley, D. C. (1985) · Clinics in Chest Medicine · doi:10.1016/s0272-5231(21)00402-0 · Cited by 382
Humoral Regulation of Red Cell Production
ERSLEV, A. (1953) · Blood · doi:10.1182/blood.v8.4.349.349 · Cited by 366
Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression
Fandrey, J. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00577.2003 · Cited by 243
Bunn, H. F. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a011619 · Cited by 234
Metadata
- Authors
- REISSMANN, K. R.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1950-04-01
- Volume
- 5
- Issue
- 4
- Pages
- 372-380
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2413031567
- Cited by
- 278
- References
- 0
- FWCI
- 6.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: STUDIES ON THE MECHANISM OF ERYTHROPOIETIC STIMULATION IN PARABIOTIC RATS DURING HYPOXIA. https://app.cochat.ai/papers/10.1182/blood.v5.4.372.372
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- REISSMANN, K. R. (1950). STUDIES ON THE MECHANISM OF ERYTHROPOIETIC STIMULATION IN PARABIOTIC RATS DURING HYPOXIA. Blood. https://doi.org/10.1182/blood.v5.4.372.372
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