The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Leukocyte interferon-induced myeloid cytoreduction in chronic myelogenous leukemia
Abstract
We investigated the antiproliferative effect of partially purified human leukocyte interferon (HuIFN-alpha) given in a dose of 9–15 X 10(6) U daily by intramuscular injection to 7 patients with chronic myelogenous leukemia (CML). Hematologic remission of the disease was obtained in 5 patients. Among the responding patients, the mean white blood cell count decreased from 97.4 X 10(3)/cu mm (range from 35 X 10(3)/cu mm to 239 X 10(3)/cu mm) to 4.2 X 10(2)/cu mm (range from 3.0 X 10(3) to 7.9 X 10(3) cu/mm). Parallel reduction occurred in serum B12, from a mean of 1,435 pg/ml to a mean of 726 pg/ml, and lactate dehydrogenase levels, from a mean of 325 mU/ml to 112 mU/ml. Enlarged spleens decreased in 3 of 3 patients. The 5 responding patients have been maintained on HuIFN-alpha, 3 X 10(6) U daily or every other day, for 6+-35+ wk.
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Cites
A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia
Klein, A. D., Kessel, A. G. V., Grosveld, G., Bartram, C. R., Hagemeijer, A., Bootsma, D., Spurr, N. K., Heisterkamp, N., Groffen, J., & Stephenson, J. R. (1982) · Nature · doi:10.1038/300765a0 · Cited by 1,378
Cited by
Clinical investigation of human alpha interferon in chronic myelogenous leukemia
Talpaz, M., Kantarjian, H., McCredie, K., Keating, M., Trujillo, J., & Gutterman, J. (1987) · Blood · doi:10.1182/blood.v69.5.1280.1280 · Cited by 328
Self-citation14 Treatment of chronic myeloid leukaemia: some topical questions
Goldman, J. M. (1997) · Baillière's Clinical Haematology · doi:10.1016/s0950-3536(97)80015-7 · Cited by 15
Metadata
- Authors
- Talpaz, M., McCredie, K., Mavligit, G., & Gutterman, J.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1983-09-01
- Volume
- 62
- Issue
- 3
- Pages
- 689-692
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2164088012
- Cited by
- 336
- References
- 1
- FWCI
- 10.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Talpaz, M., McCredie, K., Mavligit, G., & Gutterman, J. (1983). Leukocyte interferon-induced myeloid cytoreduction in chronic myelogenous leukemia. Blood. https://doi.org/10.1182/blood.v62.3.689.689
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
