The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Clinical and biologic hallmarks of the Philadelphia chromosome in childhood acute lymphoblastic leukemia
Abstract
Of 366 children with acute lymphoblastic leukemia (ALL) in whose bone marrow cells complete G-banding of chromosomes was successful, translocations were present at diagnosis in 141 (38.5%). The Philadelphia (Ph) chromosome was identified in 18 of these cases (4.9%). Features closely associated with the presence of the Ph chromosome were older age (median, 7.9 years), high leukocyte count (median, 47.3 X 10(9)/L), French-American-British L1 blast cell morphology, high incidence of CNS leukemia at diagnosis, and the common ALL immunophenotype. All patients were treated according to modern chemotherapeutic regimens for ALL used at our institution. Complete remissions were successfully induced in only 13 (72%) of the 18 patients with Ph + ALL, and only six remain free of leukemia for periods of 7+, 9+, 10+, 13+, 49+, and 70+ months. Our findings confirm the association of the Ph chromosome with classic high-risk features of ALL in children and suggest that this abnormality confers a very poor prognosis that has not yet been improved by modifications in established therapeutic regimens.
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Citations
Cites
A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia
Klein, A. D., Kessel, A. G. V., Grosveld, G., Bartram, C. R., Hagemeijer, A., Bootsma, D., Spurr, N. K., Heisterkamp, N., Groffen, J., & Stephenson, J. R. (1982) · Nature · doi:10.1038/300765a0 · Cited by 1,378
Cited by
BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
Mullighan, C. G., Miller, C. B., Radtke, I., Phillips, L. A., Dalton, J., Ma, J., White, D., Hughes, T. P., Le Beau, M. M., Pui, C.-H., et al. (2008) · Nature · doi:10.1038/nature06866 · Cited by 1,072
Outcome of Treatment in Children with Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia
Aricò, M., Valsecchi, M. G., Camitta, B., Schrappe, M., Chessells, J., Baruchel, A., Gaynon, P., Silverman, L., Janka-Schaub, G., Kamps, W., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200004063421402 · Cited by 600
Self-citationPui, C., Crist, W., & Look, A. (1990) · Blood · doi:10.1182/blood.v76.8.1449.1449 · Cited by 373
Molecular genetics of B-precursor acute lymphoblastic leukemia
Mullighan, C. G. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61203 · Cited by 247
New variant Ph translocation in chronic myeloid leukemia: t(Y;22)(p11;q11)
Gallego, M. S., Baialardo, E. M., Gutierrez, M., Bonduel, M., & Feliu, A. (1996) · Cancer Genetics and Cytogenetics · doi:10.1016/0165-4608(95)00231-6 · Cited by 7
Metadata
- Authors
- Ribeiro, R., Abromowitch, M., Raimondi, S., Murphy, S., Behm, F., & Williams, D.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1987-10-01
- Volume
- 70
- Issue
- 4
- Pages
- 948-953
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2440705721
- Cited by
- 173
- References
- 1
- FWCI
- 16.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Clinical and biologic hallmarks of the Philadelphia chromosome in childhood acute lymphoblastic leukemia. https://app.cochat.ai/papers/10.1182/blood.v70.4.948.948
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- Ribeiro, R., Abromowitch, M., Raimondi, S., Murphy, S., Behm, F., & Williams, D. (1987). Clinical and biologic hallmarks of the Philadelphia chromosome in childhood acute lymphoblastic leukemia. Blood. https://doi.org/10.1182/blood.v70.4.948.948
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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