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Bone marrow transplantation for leukemia following a new busulfan and cyclophosphamide regimen
Open accessAbstract
Busulfan 16 mg/kg and cyclophosphamide 120 mg/kg were used as conditioning prior to allogeneic marrow transplantation in 50 adult patients with acute nonlymphocytic leukemia (ANLL), acute lymphocytic leukemia (ALL), and chronic myelogenous leukemia (CML). A standard risk group of 20 patients included those with acute leukemia in remission and CML in chronic phase. A high-risk group of 30 patients included individuals with refractory acute leukemia, acute leukemia in relapse, acute leukemia following preleukemia, and CML in accelerated and blastic phase. Complete remission and sustained complete engraftment were achieved in all evaluable patients. The duration of aplasia was remarkably short (median of 8 days), resulting in a low infection rate during the period of neutropenia, a reduced need for blood product support, and a short length of hospital stay. Three-year actuarial relapse-free survival in both standard-risk (88.9% +/- 10.5%) and high- risk (50.5% +/- 9.6%) groups compares favorably with that reported with total body irradiation (TBI) containing regimens.
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Cited by
Hematopoietic Stem-Cell Transplantation
Copelan, E. A. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052638 · Cited by 2,522
Self-citationSchmidt, G. M., Horak, D. A., Niland, J. C., Duncan, S. R., Forman, S. J., Zaia, J. A., & the City of Hope–Stanford–Syntex CMV Study Group* (1991) · New England Journal of Medicine · doi:10.1056/nejm199104113241501 · Cited by 616
Gupta, A., Downey, M., Shanley, R., Jennissen, C., Miller, W. P., Lund, T. C., Orchard, P. J., & Smith, A. R. (2020) · Biology of Blood and Marrow Transplantation · doi:10.1016/j.bbmt.2019.11.014 · Cited by 21
Saute, J. A. M., Souza, C. F. M. D., Poswar, F. D. O., Donis, K. C., Campos, L. G., Deyl, A. V. S., Burin, M. G., Vargas, C. R., Matte, U. D. S., Giugliani, R., et al. (2016) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20160155 · Cited by 16
Metadata
- Authors
- Tutschka, P., Copelan, E., & Klein, J.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1987-11-01
- Volume
- 70
- Issue
- 5
- Pages
- 1382-1388
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1565345042
- Cited by
- 541
- References
- 0
- FWCI
- 9.50
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tutschka, P., Copelan, E., & Klein, J. (1987). Bone marrow transplantation for leukemia following a new busulfan and cyclophosphamide regimen. Blood. https://doi.org/10.1182/blood.v70.5.1382.1382
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