The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Serum granulocyte colony-stimulating factor levels in healthy volunteers and patients with various disorders as estimated by enzyme immunoassay
Open accessAbstract
In order to better understand the patho-physiologic role of granulocyte colony-stimulating factor (G-CSF), we estimated its serum levels in healthy persons and patients with various disorders, using a newly developed enzyme immunoassay (Motojima et al). In 49 of 56 normal healthy persons (88%), the levels were beneath the sensitivity of the assay (less than 30 pg/mL), while in the remaining seven healthy persons, the levels ranged from 33 to 163 pg/mL. On the other hand, nine of 11 patients (82%) with idiopathic aplastic anemia (AA), one patient with Fanconi's anemia, six of 12 patients (50%) with myelodysplastic syndrome (MDS), five of 12 patients (42%) with acute leukemia without any blast cells in the blood (M4: one, M5: one, L1: one, and L2: two), six of 18 patients (33%) with chronic myeloid leukemia (CML), one of two patients with chronic lymphoid leukemia (CLL), two of four patients with lung cancer, one patient with cyclic neutropenia, two of seven patients with malignant lymphoma, and four patients with acute infection had G-CSF levels ranging from 46 pg/mL to greater than 2,000 pg/mL. Interestingly, a reverse correlation between blood neutrophil count and serum G-CSF level was clearly demonstrated for aplastic anemia (r = -.8169, P less than .01). Moreover, it was found that the G-CSF level rose during the neutropenic phase of cyclic neutropenia and after chemotherapy or bone marrow transplantation (BMT) in three patients with leukemia; also high G-CSF levels were positively correlated to blood neutrophil counts in some cases of infectious disorders and lung cancer. The cellular sources and the mechanisms for production and secretion of circulating G-CSF were not investigated in this study, but the data presented here strongly indicate that G-CSF plays an important role as a circulating neutrophilopoietin.
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Citations
Cites
Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor
Nagata, S., Tsuchiya, M., Asano, S., Kaziro, Y., Yamazaki, T., Yamamoto, O., Hirata, Y., Kubota, N., Oheda, M., Nomura, H., et al. (1986) · Nature · doi:10.1038/319415a0 · Cited by 812
Self-citationWelte, K., Bonilla, M. A., Gillio, A. P., Boone, T. C., Potter, G. K., Gabrilove, J. L., Moore, M. A., O'Reilly, R. J., & Souza, L. M. (1987) · The Journal of experimental medicine · doi:10.1084/jem.165.4.941 · Cited by 412
Purification and characterization of human granulocyte colony-stimulating factor (G-CSF).
Nomura, H., Imazeki, I., Oheda, M., Kubota, N., Tamura, M., Ono, M., Ueyama, Y., & Asano, S. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04297.x · Cited by 241
Self-citationThe chromosomal gene structure and two mRNAs for human granulocyte colony-stimulating factor.
Nagata, S., Tsuchiya, M., Asano, S., Yamamoto, O., Hirata, Y., Kubota, N., Oheda, M., Nomura, H., & Yamazaki, T. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04249.x · Cited by 220
Self-citationIn vivo stimulation of granulopoiesis by recombinant human granulocyte colony-stimulating factor.
Cohen, A. M., Zsebo, K. M., Inoue, H., Hines, D., Boone, T. C., Chazin, V. R., Tsai, L., Ritch, T., & Souza, L. M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.8.2484 · Cited by 219
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Self-citationInterleukin‐1 regulation of hematopoietic growth factor production by human stromal fibroblasts
Yang, Y., Tsai, S., Wong, G. G., & Clark, S. (1988) · Journal of Cellular Physiology · doi:10.1002/jcp.1041340217 · Cited by 121
Shirafuji, N., Asano, S., Matsuda, S., Watari, K., Takaku, F., & Nagata, S. (1989) · PubMed · Cited by 102
Self-citation
Cited by
Lieschke, G., Grail, D., Hodgson, G., Metcalf, D., Stanley, E., Cheers, C., Fowler, K., Basu, S., Zhan, Y., & Dunn, A. (1994) · Blood · doi:10.1182/blood.v84.6.1737.1737 · Cited by 962
Manz, M. G., & Boettcher, S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3660 · Cited by 855
Granulocyte Colony-Stimulating Factor and Granulocyte-Macrophage Colony-Stimulating Factor
Wood, A. J. J., Lieschke, G. J., & Burgess, A. W. (1992) · New England Journal of Medicine · doi:10.1056/nejm199207023270106 · Cited by 818
Groopman, J. E., Molina, J.-M., & Scadden, D. T. (1989) · New England Journal of Medicine · doi:10.1056/nejm198911233212106 · Cited by 448
C/EBPβ is required for 'emergency' granulopoiesis
Hirai, H., Zhang, P., Dayaram, T., Hetherington, C. J., Mizuno, S.-I., Imanishi, J., Akashi, K., & Tenen, D. G. (2006) · Nature Immunology · doi:10.1038/ni1354 · Cited by 425
Metadata
- Authors
- Watari, K., Asano, S., Shirafuji, N., Kodo, H., Ozawa, K., Takaku, F., & Kamachi, S.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1989-01-01
- Volume
- 73
- Issue
- 1
- Pages
- 117-122
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1538069960
- Cited by
- 354
- References
- 9
- FWCI
- 10.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Watari, K., Asano, S., Shirafuji, N., Kodo, H., Ozawa, K., Takaku, F., & Kamachi, S. (1989). Serum granulocyte colony-stimulating factor levels in healthy volunteers and patients with various disorders as estimated by enzyme immunoassay. Blood. https://doi.org/10.1182/blood.v73.1.117.117
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