The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
All-trans retinoic acid in acute promyelocytic leukemias. II. In vitro studies: structure-function relationship
Open accessAbstract
All-trans retinoic acid induces leukemic cells from patients with acute promyelocytic leukemia (M3) to differentiate in vitro to mature granulocytes which express the CD15 antigen and are capable of respiratory burst function. Of 35 M3 samples, only one failed to respond. In eight cases, we compared the efficacy of two naturally occurring isomers of retinoic acid, all-trans RA and 13-cis RA. Both isomers induce maximal differentiation at 10(-6) mol/L. The maximal response was maintained at 10(-7) mol/L for the all-trans but not for the 13-cis RA. We also observed that the metabolites 4-oxo-all-trans and 4-oxo-13-cis were effective at 10(-6) mol/L. This 1 order of magnitude difference in the in vitro differentiating potencies of all- trans RA and 13-cis RA in the blasts of promyelocytic leukemias predicts a difference in the clinical efficacy of the two drugs.
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Bennett, J. M., Catovsky, D., Daniel, M., Flandrin, G., Galton, D. A. G., Gralnick, H. R., & Sultan, C. (1976) · British Journal of Haematology · doi:10.1111/j.1365-2141.1976.tb03563.x · Cited by 5,602
Self-citationUse of all-trans retinoic acid in the treatment of acute promyelocytic leukemia
Huang, M., Ye, Y., Chen, Sr., Chai, Jr., Lu, J., Zhoa, L., Gu, L., & Wang, Z. (1988) · Blood · doi:10.1182/blood.v72.2.567.567 · Cited by 2,445
A human retinoic acid receptor which belongs to the family of nuclear receptors
Petkovich, M., Brand, N. J., Krust, A., & Chambon, P. (1987) · Nature · doi:10.1038/330444a0 · Cited by 2,214
Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid
Breitman, T. R., Selonick, S. E., & Collins, S. J. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.5.2936 · Cited by 1,966
Castaigne, S., Chomienne, C., Daniel, M., Ballerini, P., Berger, R., Fenaux, P., & Degos, L. (1990) · Blood · doi:10.1182/blood.v76.9.1704.1704 · Cited by 1,184
Self-citationIdentification of a second human retinoic acid receptor
Brand, N., Petkovich, M., Krust, A., Chambon, P., de Thé, H., Marchio, A., Tiollais, P., & Dejean, A. (1988) · Nature · doi:10.1038/332850a0 · Cited by 1,022
A third human retinoic acid receptor, hRAR-gamma.
Krust, A., Kastner, P., Petkovich, M., Zelent, A., & Chambon, P. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.14.5310 · Cited by 677
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Sm, L., Jf, K., & Meyskens, F. L. (1987) · PubMed · Cited by 361
Cited by
Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid)
Warrell, R. P., Frankel, S. R., Miller, W. H., Scheinberg, D. A., Itri, L. M., Hittelman, W. N., Vyas, R., Andreeff, M., Tafuri, A., Jakubowski, A., et al. (1991) · New England Journal of Medicine · doi:10.1056/nejm199105163242002 · Cited by 1,251
All-trans-Retinoic Acid in Acute Promyelocytic Leukemia
Tallman, M. S., Andersen, J. W., Schiffer, C. A., Appelbaum, F. R., Feusner, J. H., Ogden, A., Shepherd, L., Willman, C., Bloomfield, C. D., Rowe, J. M., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199710093371501 · Cited by 1,073
Smith, M. A., Parkinson, D. R., Cheson, B. D., & Friedman, M. A. (1992) · Journal of Clinical Oncology · doi:10.1200/jco.1992.10.5.839 · Cited by 486
Altucci, L., Rossin, A., Raffelsberger, W., Reitmair, A., Chomienne, C., & Gronemeyer, H. (2001) · Nature Medicine · doi:10.1038/89050 · Cited by 340
Self-citationAll trans retinoic acid in acute promyelocytic leukemia
Degos, L., & Wang, Z. Y. (2001) · Oncogene · doi:10.1038/sj.onc.1204763 · Cited by 272
Self-citation
Metadata
- Authors
- Chomienne, C., Ballerini, P., Balitrand, N., Daniel, M., Fenaux, P., Castaigne, S., & Degos, L.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1990-11-01
- Volume
- 76
- Issue
- 9
- Pages
- 1710-1717
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2256214571
- Cited by
- 375
- References
- 32
- FWCI
- 12.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: All-trans retinoic acid in acute promyelocytic leukemias. II. In vitro studies: structure-function relationship. https://app.cochat.ai/papers/10.1182/blood.v76.9.1710.1710
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- Chomienne, C., Ballerini, P., Balitrand, N., Daniel, M., Fenaux, P., Castaigne, S., & Degos, L. (1990). All-trans retinoic acid in acute promyelocytic leukemias. II. In vitro studies: structure-function relationship. Blood. https://doi.org/10.1182/blood.v76.9.1710.1710
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
