The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Modulation of cell proliferation and cytokine production in acute myeloblastic leukemia by interleukin-1 receptor antagonist and lack of its expression by leukemic cells
Open accessAbstract
Interleukin-1 (IL-1) is spontaneously produced by acute myeloblastic leukemia (AML) cells. IL-1 also induces synthesis of colony-stimulating factors (CSFs) and sustains leukemic growth. An IL-1-specific inhibitor has been recently purified and cloned; this molecule binds to IL-1 receptors but has no IL-1 activity, fulfilling the characteristics of an IL-1 receptor antagonist (IL-1ra). Because high-affinity binding sites for IL-1ra were shown on AML cells by radioligand binding studies, we studied the effect of IL-1ra on the proliferative activity of blast cells isolated from 16 cases of AML. In each case, spontaneous proliferation was inhibited by addition of the IL-1ra in a dose- dependent manner (1 to 100 ng/mL). Culture supernatants of unstimulated leukemic cells contained IL-1 beta and granulocyte-macrophage CSF (GM- CSF), but when incubated with the IL-1ra, a reduction or disappearance of GM-CSF was observed in 8 of 10 cases, whereas spontaneous IL-1 production was reduced in four of seven cases. By Northern hybridization, IL-1 beta gene transcripts were shown in 20 of 23 AML cases, whereas IL-1ra-specific messenger RNA was present in only two of the patients studied. These data show a role for IL-1 in the spontaneous proliferation and cytokine production of AML cells and suggest that an imbalanced synthesis of IL-1 and of its natural receptor antagonist may contribute to the unrestricted growth of AML cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In particular, the SASP-associated cytokines TNF, IFN, and IL-6 all play significant roles in the pathogenesis of myeloproliferative neoplasms (MPNs), 52 MDSs, 53 and acute myeloid leukemia (AML).54”
From Inflammatory bone marrow microenvironment (2019) · cites this paper as [54]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
Feinberg, A. P., & Vogelstein, B. (1983) · Analytical Biochemistry · doi:10.1016/0003-2697(83)90418-9 · Cited by 24,512
Autocrine growth factors and cancer
Sporn, M. B., & Roberts, A. B. (1985) · Nature · doi:10.1038/313745a0 · Cited by 1,425
Interleukin-1 and Its Biologically Related Cytokines
Dinarello, C. A. (1989) · Advances in immunology · doi:10.1016/s0065-2776(08)60642-2 · Cited by 1,145
Self-citationEisenberg, S. P., Evans, R. J., Arend, W. P., Verderber, E. L., Brewer, M. T., Hannum, C. H., & Thompson, R. C. (1990) · Nature · doi:10.1038/343341a0 · Cited by 1,084
Metcalf, D. (1989) · Nature · doi:10.1038/339027a0 · Cited by 1,023
Schindler, R., Mancilla, J., Endres, S., Ghorbani, R., Clark, S., & Dinarello, C. (1990) · Blood · doi:10.1182/blood.v75.1.40.40 · Cited by 1,012
Self-citationBiological properties of recombinant human monocyte-derived interleukin 1 receptor antagonist.
Arend, W. P., Welgus, H. G., Thompson, R. C., & Eisenberg, S. P. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114622 · Cited by 576
A urine inhibitor of interleukin 1 activity that blocks ligand binding.
Seckinger, P., Lowenthal, J. W., Williamson, K., Dayer, J. M., & MacDonald, H. R. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.5.1546 · Cited by 345
Autocrine secretion of GM-CSF in acute myeloblastic leukemia
Young, D., & Griffin, J. (1986) · Blood · doi:10.1182/blood.v68.5.1178.1178 · Cited by 270
Interleukin-1 induces interleukin-6 production in peripheral blood monocytes
Tosato, G., & Jones, K. (1990) · Blood · doi:10.1182/blood.v75.6.1305.1305 · Cited by 251
Cited by
Sorted by citations
Interleukin-1 and interleukin-1 antagonism
Dinarello, C. A. (1991) · Blood · doi:10.1182/blood.v77.8.1627.1627 · Cited by 2,292
Self-citationMolecular Cloning of the Interleukin-1β Converting Enzyme
Cerretti, D. P., Kozlosky, C. J., Mosley, B., Nelson, N. C., Ness, K. V., Greenstreet, T. A., March, C. J., Kronheim, S. R., Druck, T., Cannizzaro, L. A., et al. (1992) · Science · doi:10.1126/science.1373520 · Cited by 1,147
The Role of Interleukin-1 in Disease
Epstein, F. H., Dinarello, C. A., & Wolff, S. M. (1993) · New England Journal of Medicine · doi:10.1056/nejm199301143280207 · Cited by 954
Self-citationInterleukin-1, Interleukin-1 Receptors and Interleukin-1 Receptor Antagonist
Dinarello, C. A. (1998) · International Reviews of Immunology · doi:10.3109/08830189809043005 · Cited by 761
Self-citationInterleukin-1 Receptor Antagonist
Arend, W. P. (1993) · Advances in immunology · doi:10.1016/s0065-2776(08)60535-0 · Cited by 670
Lewis, A. M., Varghese, S., Xu, H., & Alexander, H. R. (2006) · Journal of Translational Medicine · doi:10.1186/1479-5876-4-48 · Cited by 442
Anticytokine Strategies in the Treatment of the Systemic Inflammatory Response Syndrome
Dinarello, C. A. (1993) · JAMA · doi:10.1001/jama.1993.03500140081040 · Cited by 404
Self-citationDinarello, C. A. (1991) · The Journal of Infectious Diseases · doi:10.1093/infdis/163.6.1177 · Cited by 396
Self-citationCytokines as Endogenous Pyrogens
Dinarello, C. A. (1999) · The Journal of Infectious Diseases · doi:10.1086/513856 · Cited by 397
Self-citationThe NLRP3 inflammasome in health and disease: the good, the bad and the ugly
Menu, P., & Vince, J. E. (2011) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2011.04440.x · Cited by 396
Vannier, E. G., Miller, L. C., & Dinarello, C. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.9.4076 · Cited by 320
Self-citationEstrov, Z. E., Shishodia, S., Faderl, S. H., Harris, D., Van, Q., Kantarjian, H. M., Talpaz, M., & Aggarwal, B. B. (2003) · Blood · doi:10.1182/blood-2002-11-3550 · Cited by 306
Song, X., Krelin, Y., Dvorkin, T., Björkdahl, O., Segal, S., Dinarello, C. A., Voronov, E., & Apte, R. N. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.12.8200 · Cited by 290
Self-citationWhy not treat human cancer with interleukin-1 blockade?
Dinarello, C. A. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9229-0 · Cited by 287
Self-citationInducible expression of PTX3, a new member of the pentraxin family, in human mononuclear phagocytes
Alles, V. V., Bottazzi, B., Peri, G., Golay, J., Introna, M., & Mantovani, A. (1994) · Blood · doi:10.1182/blood.v84.10.3483.3483 · Cited by 260
Barreyro, L., Will, B., Bartholdy, B., Zhou, L., Todorova, T. I., Stanley, R. F., Ben-Neriah, S., Montagna, C., Parekh, S., Pellagatti, A., et al. (2012) · Blood · doi:10.1182/blood-2012-01-404699 · Cited by 201
Poutsiaka, D., Clark, B., Vannier, E. G., & Dinarello, C. A. (1991) · Blood · doi:10.1182/blood.v78.5.1275.1275 · Cited by 197
Self-citationRole of Interleukin‐l in Infectious Diseases
Dinarello, C. A. (1992) · Immunological Reviews · doi:10.1111/j.1600-065x.1992.tb01411.x · Cited by 175
Self-citationHistone Deacetylase Inhibitors for Treating a Spectrum of Diseases Not Related to Cancer
Dinarello, C. A., Fossati, G., & Mascagni, P. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00116 · Cited by 160
Self-citationFerretti, M., Casini–Raggi, V., Pizarro, T. T., Eisenberg, S. P., Nast, C. C., & Cominelli, F. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117345 · Cited by 154
Cytokines: Agents provocateurs in hemodialysis?
Dinarello, C. A. (1992) · Kidney International · doi:10.1038/ki.1992.105 · Cited by 149
Self-citationMcCall, R. D., Haskill, S., Zimmermann, E. M., Lund, P. K., Thompson, R. C., & Sartor, R. B. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90755-2 · Cited by 128
Selective killing of candidate AML stem cells by antibody targeting of IL1RAP
Askmyr, M., Ågerstam, H., Hansen, N., Gordon, S., Arvanitakis, A., Rissler, M., Juliusson, G., Richter, J., Järås, M., & Fioretos, T. (2013) · Blood · doi:10.1182/blood-2012-09-458935 · Cited by 127
Ågerstam, H., Karlsson, C., Hansen, N., Sandén, C., Askmyr, M., von Palffy, S., Högberg, C., Rissler, M., Wunderlich, M., Juliusson, G., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1422749112 · Cited by 111
Perregaux, D. G., & Gabel, C. A. (1998) · PubMed · Cited by 96
Constitutive NF-κB activation in AML: Causes and treatment strategies
Bosman, M. C. J., Schuringa, J. J., & Vellenga, E. (2015) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2015.10.001 · Cited by 95
Interleukin‐1β and interleukin‐18: regulation and activity in local inflammation
Delaleu, N., & Bickel, M. (2004) · Periodontology 2000 · doi:10.1111/j.0906-6713.2004.003569.x · Cited by 94
IL‐1 family in breast cancer: Potential interplay with leptin and other adipocytokines
Perrier, S., Caldefie‐Chezet, F., & Vasson, M. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.12.030 · Cited by 93
Modalities for reducing interleukin 1 activity in disease
Dinarello, C. A. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90042-j · Cited by 90
Self-citationPerregaux, D. G., & Gabel, C. A. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.5.2469 · Cited by 85
Inflammatory bone marrow microenvironment
Leimkühler, N. B., & Schneider, R. K. (2019) · Hematology · doi:10.1182/hematology.2019000045 · Cited by 82
THERMOREGULATION AND THE PATHOGENESIS OF FEVER
Dinarello, C. A. (1996) · Infectious Disease Clinics of North America · doi:10.1016/s0891-5520(05)70306-8 · Cited by 77
Self-citationEstrov, Z. E., Manna, S. K., Harris, D., Van, Q., Estey, E. H., Kantarjian, H. M., Talpaz, M., & Aggarwal, B. B. (1999) · Blood · doi:10.1182/blood.v94.8.2844.420k43_2844_2853 · Cited by 77
Autonomous growth of blast cells is associated with reduced survival in acute myeloblastic leukemia
Hunter, A., Rogers, S., Roberts, I., Barrett, A., & Russell, N. H. (1993) · Blood · doi:10.1182/blood.v82.3.899.899 · Cited by 75
Wetzler, M., Kurzrock, R., Estrov, Z. E., Kantarjian, H. M., Gisslinger, H., Underbrink, M., & Talpaz, M. (1994) · Blood · doi:10.1182/blood.v84.9.3142.3142 · Cited by 70
GATA Factor-Dependent Positive-Feedback Circuit in Acute Myeloid Leukemia Cells
Katsumura, K. R., Ong, I. M., DeVilbiss, A., Sanalkumar, R., & Bresnick, E. H. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.058 · Cited by 70
Autocrine Induction of the Human Pro-IL-1β Gene Promoter by IL-1β in Monocytes
Toda, Y., Tsukada, J., Misago, M., Kominato, Y., Auron, P. E., & Tanaka, Y. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.4.1984 · Cited by 67
Monocyte-related cytokines in acute myocardial infarction
Tashiro, H., Shimokawa, H., Yamamoto, K., Nagano, M., Momohara, M., Muramatu, K.-H., & Takeshita, A. (1995) · American Heart Journal · doi:10.1016/0002-8703(95)90350-x · Cited by 66
Autocrine growth factors and leukaemic haemopoiesis
Russell, N. H. (1992) · Blood Reviews · doi:10.1016/0268-960x(92)90026-m · Cited by 58
Autocrine interleukin-1beta production in leukemia: evidence for the involvement of mutated RAS.
Beaupre, D. M., Talpaz, M., Marini, F. C., Cristiano, R. J., Roth, J. A., Estrov, Z., Albitar, M. X., Freedman, M. H., & Kurzrock, R. (1999) · PubMed · Cited by 54
Dinarello, C. A. (1994) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60429-9 · Cited by 53
Self-citationGuo, C., Dower, S., Holowka, D., & Baird, B. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.46.27562 · Cited by 52
Honda, H., Nagamachi, A., & Inaba, T. (2014) · Oncogene · doi:10.1038/onc.2014.196 · Cited by 50
Wetzler, M., Kurzrock, R., Estrov, Z. E., Estey, E. H., & Talpaz, M. (1995) · Leukemia Research · doi:10.1016/0145-2126(94)00059-j · Cited by 47
Böttcher, M., Panagiotidis, K., Bruns, H., Stumpf, M., Völkl, S., Geyh, S., Dietel, B., Schroeder, T. A., Mackensen, A., & Mougiakakos, D. (2022) · Blood Advances · doi:10.1182/bloodadvances.2021005938 · Cited by 40
Arondel, J., Singer, M., Matsukawa, A., Zychlinsky, A., & Sansonetti, P. J. (1999) · Infection and Immunity · doi:10.1128/iai.67.11.6056-6066.1999 · Cited by 39
Estrov, Z., Black, R., Sleath, P. R., Harris, D., Van, Q., LaPushin, R., Estey, E., & Talpaz, M. (1995) · Blood · doi:10.1182/blood.v86.12.4594.bloodjournal86124594 · Cited by 39
Li, J., Volk, A. G., Zhang, J., Cannova, J., Dai, S., Hao, C., Hu, C.-L., Sun, J., Xu, Y., Wei, W., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.14220 · Cited by 38
Vannier, E. G., Malefyt, R. D. W., Salazar-Montes, A., de Vries, J. E., & Dinarello, C. A. (1996) · Blood · doi:10.1182/blood.v87.8.3307.bloodjournal8783307 · Cited by 37
Self-citationRole of cytokines in AIDS wasting
Chang, H. R., Dulloo, A. G., & Bistrian, B. R. (1998) · Nutrition · doi:10.1016/s0899-9007(98)00108-7 · Cited by 35
Tao, M., Li, Y., Nayini, J., Andrews, C., Huang, R., Devemy, E., Song, S., Venugopal, P., & Preisler, H. D. (2000) · Cytokine · doi:10.1006/cyto.2000.0666 · Cited by 35
Nishi, O., Nishi, K., & Ohmoto, Y. (1994) · British Journal of Ophthalmology · doi:10.1136/bjo.78.12.917 · Cited by 31
Cominelli, F., Bortolami, M., Pizarro, T. T., Monsacchi, L., Ferretti, M., Brewer, M. T., Eisenberg, S. P., & Ng, R. K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37468-9 · Cited by 31
Schirò, R., Longoni, D. V., Rossi, V., Maglia, O., Doni, A., Arsura, M., Carrara, G., Masera, G., Vannier, E. G., & Dinarello, C. A. (1994) · Blood · doi:10.1182/blood.v83.2.460.460 · Cited by 30
Self-citationTh17 related cytokines in acute myeloid leukemia
Li, P. (2012) · Frontiers in bioscience · doi:10.2741/4052 · Cited by 29
Investigation of the Interleukin 1 Gene Cluster and Its Association with Acute Pancreatitis
Smithies, A., Sargen, K., Demaine, A. G., & Kingsnorth, A. N. (2000) · Pancreas · doi:10.1097/00006676-200004000-00003 · Cited by 29
Miki, C., Tonouchi, H., Wakuda, R., Hatada, T., Inoue, Y., Minato, E., Kobayashi, M., & Kusunoki, M. (2002) · Cancer · doi:10.1002/cncr.10324 · Cited by 29
Molecular Basis of Selective Cytokine Signaling Inhibition by Antibodies Targeting a Shared Receptor
Fields, J. K., Kihn, K. C., Birkedal, G. S., Klontz, E. H., Sjöström, K., Günther, S., Beadenkopf, R., Forsberg, G., Liberg, D., Snyder, G. A., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.779100 · Cited by 26
Rambaldi, A., Bettoni, S., Tosi, S., Giudici, G., Schirò, R., Borleri, G., Abbate, M., Chiaffarino, F., Colotta, F., & Barbui, T. (1993) · Blood · doi:10.1182/blood.v81.5.1376.1376 · Cited by 26
Self-citationHsieh, T. C., & Chiao, J. W. (1995) · Cancer Letters · doi:10.1016/0304-3835(95)03876-x · Cited by 25
Cytokine gene activity in AML cells in vivo in patients
Gao, X.-Z., Bi, S., Chopra, H. K., Devemy, E., Venugopal, P., Li, Y., Hsu, W.-T., Loew, J. M., Galvez, A. G., Gregory, S. A., et al. (1998) · Leukemia Research · doi:10.1016/s0145-2126(98)00024-1 · Cited by 23
Blocking interleukin-1 receptors
Dinarello, C. A. (1994) · International Journal of Clinical & Laboratory Research · doi:10.1007/bf02593903 · Cited by 24
Self-citationStošić‐Grujičić, S., Basara, N., Milenković, P., & Dinarello, C. A. (1995) · Journal of Chemotherapy · doi:10.1179/joc.1995.7.1.67 · Cited by 23
Self-citationModalities for reducing interleukin 1 activity in disease
Dinarello, C. A. (1993) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(93)90200-4 · Cited by 23
Self-citationRole of the Nitric Oxide/Cyclic GMP/Ca2+ Signaling Pathway in the Pyrogenic Effect of Interleukin-1β
Palmi, M., & Meini, A. (2002) · Molecular Neurobiology · doi:10.1385/mn:25:2:133 · Cited by 23
Interleukin pattern of Apert fibroblasts in vitro
Bodo, M., Carinci, F., Baroni, T., Becchetti, E., Bellucci, C., Giammarioli, M., Pezzetti, F., Tognon, M. G., & Carinci, P. (1998) · European Journal of Cell Biology · doi:10.1016/s0171-9335(98)80072-1 · Cited by 22
Blocking lnterleukin-1 in Disease
Dinarello, C. A. (2008) · Blood Purification · doi:10.1159/000170105 · Cited by 22
Self-citationBruserud, B. F. O. (1997) · Platelets · doi:10.1080/09537109777087 · Cited by 19
Bruserud, Ø., Nesthus, I., Bühring, H., & Pawelec, G. (1995) · Leukemia Research · doi:10.1016/0145-2126(94)00062-f · Cited by 19
The management of acute myelogenous leukemia in the elderly: Ten‐year experience in 118 patients
Bassan, R., Buelli, M., Viero, P., Minotti, C., & Barbui, T. (1992) · Hematological Oncology · doi:10.1002/hon.2900100503 · Cited by 19
Self-citationDinarello, C. A. (1994) · The Keio Journal of Medicine · doi:10.2302/kjm.43.131 · Cited by 18
Self-citationInterleukin-1, interleukin-1 receptor, and interleukin-1 receptor antagonist
Espat, N. J., Rogy, M. A., Copeland, E. M., & Moldawer, L. L. (1994) · Proceedings of The Nutrition Society · doi:10.1079/pns19940044 · Cited by 18
Tao, M., Li, Y., Nayini, J., Sivaraman, S., Song, S., Larson, A. W., Toofanfard, M., Chen, H., Venugopal, P., & Preisler, H. D. (2001) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428190109057966 · Cited by 18
Nedumpun, T., Techakriengkrai, N., Thanawongnuwech, R., & Suradhat, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00579 · Cited by 17
Furukawa, Y., Kikuchi, J., Terui, Y., Kitagawa, S., Ohta, M., Miura, Y., & Saito, M. (1995) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1995.tb03041.x · Cited by 16
Cytokine Antagonists in Infectious and Inflammatory Disorders
Catania, A., Manfredi, M. G., Airaghi, L., Ceriani, G., Gandino, A., & Lipton, J. M. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb39655.x · Cited by 15
Establishment of human acute myelogenous leukemia lines secreting interleukin‐1β in SCID mice
Giavazzi, R., Berardino, C. D., Garofalo, A., Motta, T., Gobbi, A., Scanziani, E., Giudici, G., Galli, M., Mayo, J. G., Barbui, T., et al. (1995) · International Journal of Cancer · doi:10.1002/ijc.2910610223 · Cited by 15
Self-citationRegion-Specific Methylation Profiling in Acute Myeloid Leukemia
Cecotka, A., & Polańska, J. (2018) · Interdisciplinary Sciences Computational Life Sciences · doi:10.1007/s12539-018-0285-4 · Cited by 13
Bruserud, Ø., Aasen, I., Akselsen, P. E., Bergheim, J., Rasmussen, G., & Nesthus, I. (1996) · European Journal Of Haematology · doi:10.1111/j.1600-0609.1996.tb00495.x · Cited by 13
Effects of endogenous interleukin 1 on blast cells derived from acute myelogenous leukemia patients
Bruserud, Ø. (1996) · Leukemia Research · doi:10.1016/0145-2126(95)00112-3 · Cited by 13
Peleg, S., Qiu, H., Reddy, S. V., Harris, D., Van, Q., Estey, E. H., Talpaz, M., & Estrov, Z. E. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119696 · Cited by 13
Role of Interleukin-1 Inhibitory Molecules in Therapy of Acute and Chronic Myelogenous Leukemia
Estrov, Z. E., Kurzrock, R., & Talpaz, M. (1993) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428199309148197 · Cited by 13
Weiß, T., Vitacolonna, M., & Zöller, M. (2009) · Journal of Immunotherapy · doi:10.1097/cji.0b013e31819b7b9e · Cited by 12
8 Down-regulation of cytokine action
McCarthy, P. L. (1994) · Baillière s Clinical Haematology · doi:10.1016/s0950-3536(05)80011-3 · Cited by 13
Fitness landscapes and the myeloid leukemias
Preisler, H. D. (1999) · Leukemia Research · doi:10.1016/s0145-2126(98)00157-x · Cited by 11
Treatment of Myelodysplastic Syndromes
Komrokji, R. S. (2023) · Wiley eBooks · doi:10.1002/9781119823193.ch13 · Cited by 10
Cytokines, molecular biological abnormalities, and acute myelogenous leukemia
Preisler, H. D., Bi, S., Venugopal, P., & Raza, A. (1997) · Leukemia Research · doi:10.1016/s0145-2126(96)00097-5 · Cited by 10
Vinante, F., Rigo, A., Tecchio, C., Patuzzo, C., Ricetti, M. M., Morosato, L., Cassatella, M. A., Chilosi, M., & Pizzolo, G. (1996) · PubMed · Cited by 9
Role of Cytokines in Patients on Dialysis
Pereira, B. J. G., & Dinarello, C. A. (1995) · The International Journal of Artificial Organs · doi:10.1177/039139889501800601 · Cited by 10
Self-citationInterleukin-1 and its inhibitors: Implications for disease biology and therapy
Estrov, Z. E., Kurzrock, R., & Talpaz, M. (1995) · Cancer treatment and research · doi:10.1007/978-1-4613-1241-3_3 · Cited by 8
Słotwińska, S. M. (2013) · Open Journal of Immunology · doi:10.4236/oji.2013.31002 · Cited by 7
The Role of Interleukin-1 in Septic Shock
Dinarello, C. A., Aiura, K., & Gelfand, J. A. (1992) · Yearbook of intensive care and emergency medicine · doi:10.1007/978-3-642-84734-9_3 · Cited by 7
Self-citationBruserud, �., Nesthus, I., & Pawelec, G. (1995) · Cancer Chemotherapy and Pharmacology · doi:10.1007/bf00685631 · Cited by 7
Interleukin‐1β stimulation of 45 Ca2+ release from rat striatal slices
Palmi, M., Frosini, M., & Sgaragli, G. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15595.x · Cited by 7
Stošić‐Grujičić, S., Basara, N., & Dinarello, C. A. (1999) · Clinical & Laboratory Haematology · doi:10.1046/j.1365-2257.1999.00221.x · Cited by 7
Self-citationGrowth Factors in the Management of Adult Acute Leukemia
Bernstein, S. H. (1993) · Hematology/Oncology Clinics of North America · doi:10.1016/s0889-8588(18)30266-1 · Cited by 7
Acute myeloid leukemia in elderly patients: New targets, new therapies
Park, H. J., & Gregory, M. A. (2023) · Aging and Cancer · doi:10.1002/aac2.12065 · Cited by 8
Fernández‐Fernández, F. J., Álvarez-Fernández, J. C., Picos, E. R., Garrido, J. A., & Sesma, P. (2010) · Acta Medica (Hradec Kralove Czech Republic) · doi:10.14712/18059694.2016.75 · Cited by 6
Colotta, F., Ghezzi, P., & Mantovani, A. (1998) · Elsevier eBooks · doi:10.1016/b978-012498340-3/50002-6 · Cited by 6
Gene expression, biological effects and clinical aspects of lymphokines.
Tuyt, L., Dokter, W., & Vellenga, E. (1997) · Critical reviews in oncology/hematology · doi:10.1016/s1040-8428(97)10006-3 · Cited by 8
Metadata
- Authors
- Rambaldi, A., Torcia, M., Bettoni, S., Vannier, E., Barbui, T., Shaw, A., Dinarello, C., & Cozzolino, F.
- Affiliations
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Division of Hematology, Ospedali Riuniti, Bergamo, Italy.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1991-12-15
- Volume
- 78
- Issue
- 12
- Pages
- 3248-3253
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2395259494
- Cited by
- 129
- References
- 29
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 3 · 2012: 3
- FWCI
- 9.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion, other-oa)
- Funders
- National Institutes of Health (15614, AI‐15614)
- National Institute of Allergy and Infectious Diseases (AI‑15614)
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Keywords
- acute myeloid leukemia, interleukin-1 receptor antagonist, IL-1β, cell proliferation, cytokine production, GM-CSF, leukemia cell proliferation
- MeSH terms
- Binding, Competitive, Cell Division, Humans, Interleukin-1, Kinetics, Proteins, Receptors, Immunologic, Recombinant Proteins, RNA, Messenger, Sialoglycoproteins, Tumor Cells, Cultured, Blotting, Northern, Leukemia, Myeloid, Acute, Gene Expression, Granulocyte-Macrophage Colony-Stimulating Factor, Cytokines, Receptors, Interleukin-1, Interleukin 1 Receptor Antagonist Protein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
