An AML1/ETO fusion transcript is consistently detected by RNA-based polymerase chain reaction in acute myelogenous leukemia containing the (8;21)(q22;q22) translocation

Downing, JR; Head, DR; Curcio-Brint, AM; Hulshof, MG; Motroni, TA; Raimondi, SC; Carroll, AJ; Drabkin, HA; Willman, C; Theil, KS

doi:10.1182/blood.v81.11.2860.2860

An AML1/ETO fusion transcript is consistently detected by RNA-based polymerase chain reaction in acute myelogenous leukemia containing the (8;21)(q22;q22) translocation

The 8;21 translocation is one of the most common chromosomal translocations in acute myelogenous leukemia (AML), accounting for 40% of pediatric AML with French-American-British (FAB)-M2 morphology. The chromosomal breakpoints have recently been identified at the molecular level and shown to invo…