Induction of monocytic differentiation and tumorigenicity by v-Ha-ras in differentiation arrested hematopoietic cells
Abstract
Activated ras genes are often associated with human myeloid leukemias with a monocytic differentiated phenotype. To investigate the role of the activated ras gene in leukemogenesis, a myeloid nontumorigenic cell line (FDC-P1) was infected with a selectable retroviral vector carrying the v-Ha-ras gene (H1neo). Infected FDC-P1 cells were not only tumorigenic, but also showed increased monocytic differentiation in vitro. Monocytic differentiation and tumorigenicity in vivo were correlated with several-fold increased levels of activated ras gene expression. Tumorigenic cells were arrested with respect to monocytic marker expression at a much later stage of macrophage differentiation than the parental noninfected FDC-P1 cells. These data thus suggest a model of how activated ras genes could be involved in the preferential induction of hematopoietic malignancies with a myelomonocytic phenotype.
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Ras signal transduction plays an important role in myeloid differentiation.
“Ras signal transduction has been demonstrated to play an important role in myeloid differentiation (47)(48)(49)(50)”
From c-Jun Is a JNK-independent Coactivator of the PU.1 Transcription Factor (1999) · cites this paper as [48]
Ras plays an important role in myeloid differentiation.
“In particular, Ras has been demonstrated to play an important role in myeloid differentiation.”
From c-Jun Is a JNK-independent Coactivator of the PU.1 Transcription Factor (1999) · cites this paper as [48]
A number of hematopoietic cell lines undergo spontaneous monocytic differentiation in response to expression of activated Ras.
“while a number of hematopoietic cell lines undergo spontaneous monocytic differentiation in response to expression of activated Ras (48,49).”
From c-Jun Is a JNK-independent Coactivator of the PU.1 Transcription Factor (1999) · cites this paper as [48]
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References 45 · Cited by 44
- Authors
- Hibi, S., Lohler, J., Friel, J., Stocking, C., & Ostertag, W.
- Affiliations
- Leibniz Institute of Virology (LIV) (DE)
- Heinrich-Pette-Institut fur Experimentelle Virologie und Immunologie an der Universitat Hamburg, Germany.
- ORCID
- Stocking, C
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1993-04-01
- Volume
- 81
- Issue
- 7
- Pages
- 1841-1848
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2415311436
- Cited by
- 44
- References
- 45
- Citations by year
- 2025: 3 · 2024: 3 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Keywords
- v-Ha-ras, monocyte differentiation, tumorigenicity, myeloid leukemia, leukemogenesis, FDC-P1 cells, retroviral vectors, macrophage differentiation, hematologic malignancies
- MeSH terms
- Animals, Cell Differentiation, Cell Line, Cell Transformation, Neoplastic, Clone Cells, Gene Expression Regulation, Genetic Vectors, Hematopoietic Stem Cells, Histiocytes, Macrophages, Mice, Inbred DBA, Monocytes, Genes, ras, Retroviridae, Tumor Cells, Cultured, Biomarkers, Tumor, Immunophenotyping, Macrophage Colony-Stimulating Factor, Mice
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