The idiopathic hypereosinophilic syndrome
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Approximately 20% to 50% of patients with hypereosinophilic syndrome exhibit inflammation or fibrosis in the heart.
“Approximately 20% to 50% of patients with hypereosinophilic syndrome exhibit inflammation or fibrosis in the heart”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [199]
The Clinical Manifestations section describes cardiac disease as frequent in HES and says heart damage can progress from necrosis to fibrosis. The retrieved passages do not establish that inflammation or fibrosis occurs in approximately 20% to 50% of patients; the numerical range is unsupported by the available text. (LLM, conf=0.83)
Experimental — accuracy not yet measuredEosinophil-related autoimmune disorders are strongly linked to cardiovascular manifestations including myocarditis.
“eosinophil-related autoimmune disorders are strongly linked to cardiovascular manifestations including myocarditis.”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [199]
The Clinical Manifestations section says cardiac disease is frequent in hypereosinophilic syndrome and describes acute eosinophilic myocarditis. It does not establish that eosinophil-related autoimmune disorders, specifically, are strongly linked to these manifestations; it discusses hypereosinophilic syndrome and several other causes of eosinophilia. (LLM, conf=0.86)
Experimental — accuracy not yet measuredOver 40% of patients with eosinophilic granulomatosis with polyangiitis experience cardiovascular complications.
“over 40% of patients with eosinophilic granulomatosis with polyangiitis, also known as ChurgStrauss, experience cardiovascular complications.”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [199]
The Clinical Manifestations section describes cardiac disease in idiopathic hypereosinophilic syndrome, while the Differential Diagnosis of HES section discusses Churg–Strauss syndrome without giving a rate of cardiovascular complications. Searches for Churg–Strauss cardiac involvement and 40% found no passage supporting the claimed proportion. (LLM, conf=0.75)
Experimental — accuracy not yet measured
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Cites
The cardiovascular manifestations of the hypereosinophilic syndrome
Parrillo, J. E., Borer, J. S., Henry, W. L., Wolff, S. M., & Fauci, A. S. (1979) · The American Journal of Medicine · doi:10.1016/0002-9343(79)90227-4 · Cited by 314 · see citing works
Flagged first, then by citations
Research works printed but not linked: 5
- Spry CJF: Eosinophils. A Comprehensive Review and Guide to the Scientific and Medical Literature. Oxford, UK, Oxford Medical Publications, 1988
- Chusid MJ, Dale DC, West BC, Wolff SM: The hypereo- sinophilic syndrome: Analysis of fourteen cases with review of the literature. Medicine (Baltimore) 54: 1, 1975
- Spry CJ, Take M, Tai PC: Eosinophilic disorders affecting the myocardium and endocardium: A review. Heart Vessels Suppl 1:240, 1985
- Longworth DL, Weller PF: Hyperinfection syndrome with strongyloidiasis, in Remington JS, Swartz MN (eds): Current Clini- cal Topics in Infectious Diseases. New York, NY, McGraw-Hill, 1986, p l 293.
- Benvenisti DS, Ultmann JE: Eosinophilic leukemia. Report of five cases and review of literature. Ann Intern Med 71:731, 1969 300.
Cited by
Sorted by citations
Eosinophil-associated gastrointestinal disorders: A world-wide-web based registry
Guajardo, J. R., Plotnick, L. M., Fende, J. M., Collins, M. H., Putnam, P. E., & Rothenberg, M. E. (2002) · The Journal of Pediatrics · doi:10.1067/mpd.2002.127663 · Cited by 196 · see citing works
Autoimmune Myocarditis, Old Dogs and New Tricks.
Won, T., Song, E. J., Kalinoski, H. M., Moslehi, J. J., & Čiháková, D. (2024) · Circulation Research · doi:10.1161/circresaha.124.323816 · Cited by 51 · see citing works
Anti-IL-5 and hypereosinophilic syndromes
SUTTON, S., ASSAAD, A., & ROTHENBERG, M. (2005) · Clinical Immunology · doi:10.1016/j.clim.2005.02.006 · Cited by 40 · see citing works
Hypereosinophilia causes progressive cardiac pathologies in mice
Diny, N. L., Wood, M. K., Won, T., Talor, M. V., Lukban, C., Bedja, D., Wang, N., Kalinoski, H., Daoud, A., Talbot, C. C., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107990 · Cited by 7 · see citing works
- Authors
- Weller, P., & Bubley, G.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1994-05-15
- Volume
- 83
- Issue
- 10
- Pages
- 2759-2779
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W110944710
- Cited by
- 929
- References
- 1
- Citations by year
- 2026: 8 · 2025: 21 · 2024: 24 · 2023: 13 · 2022: 29 · 2021: 22 · 2020: 20 · 2019: 19 · 2018: 19 · 2017: 24 · 2016: 27 · 2015: 29 · 2014: 38 · 2013: 35 · 2012: 42
- FWCI
- 18.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute for Health and Care Research
- National Institutes of Health (1p50hl046563-01, AI20241)
- National Heart, Lung, and Blood Institute (HL-46563)
- National Institute of Allergy and Infectious Diseases (AI22571, AI 20241, R01AI022571)
- Topics
- Health Sciences › Medicine › Rheumatology › Eosinophilic Disorders and Syndromes
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- idiopathic hypereosinophilic syndrome, eosinophilia, hypereosinophilic syndrome
- MeSH terms
- Diagnosis, Differential, Humans, Hypereosinophilic Syndrome
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