Distinctions Between CD8+ and CD4+ T-Cell Regenerative Pathways Result in Prolonged T-Cell Subset Imbalance After Intensive Chemotherapy

Mackall, Crystal L.; Fleisher, Thomas A.; Brown, Margaret R.; Andrich, Mary P.; Chen, Clara C.; Feuerstein, Irwin M.; Magrath, Ian T.; Wexler, Leonard H.; Dimitrov, Dimiter S.; Gress, Ronald E.

doi:10.1182/blood.v89.10.3700

Distinctions Between CD8+ and CD4+ T-Cell Regenerative Pathways Result in Prolonged T-Cell Subset Imbalance After Intensive Chemotherapy

Rapid recovery of CD4+ T cells after intensive chemotherapy is limited by an age-dependent decline in thymopoiesis. Here we sought to determine whether similar limitations exist for CD8+ T-cell regeneration. After intensive chemotherapy, CD8+ T cells had a faster effective doubling time than CD4+…