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Multiple inhibitory cytokines induce deregulated progenitor growth and apoptosis in hematopoietic cells from Fac-/- mice

Haneline, Laura S., Broxmeyer, Hal E., Cooper, Scott, Hangoc, Giao, Carreau, Madeleine, Buchwald, Manuel, Clapp, D. Wade·1998·Blood
DOI 10.1182/blood.v91.11.4092
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Abstract

We used a murine model containing a disruption of the murine homologue (Fac) of Fanconi Anemia group C (FAC) to evaluate the role of Fac in the pathogenesis of bone marrow (BM) failure. Methylcellulose cultures of BM cells fromFac−/− and Fac+/+ mice were established to examine the growth of multipotent and lineage-restricted progenitors containing inhibitory cytokines, including interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), and macrophage inflammatory protein-1α (MIP-1α). Clonogenic growth of Fac−/− progenitors was reduced by 50% at 50- to 100-fold lower concentrations of all inhibitory cytokines evaluated. We hypothesized that the aberrant responsiveness to inhibitory cytokines in clonogenic cells may be a result of deregulated apoptosis. To test this hypothesis, we performed the TUNEL assay on purified populations of primary BM cells enriched for hematopoietic progenitors or differentiated myeloid cells. After stimulation with TNF-α, accentuated apoptosis was observed in both populations of Fac−/− cells. In addition, deregulated apoptosis was also noted in the most immature phenotypic population of hematopoietic cells after stimulation with MIP-1α.Together these data suggest a role of Fac in affecting the signaling of multiple cytokine pathways and support cytokine-mediated apoptosis as a major mechanism responsible for BM failure observed in FA patients.

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Cited by

Metadata

Authors
Haneline, L. S., Broxmeyer, H. E., Cooper, S., Hangoc, G., Carreau, M., Buchwald, M., & Clapp, D. W.
Affiliations
1 From the Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine; the Department of Microbiology/Immunology, Indiana University School of Medicine; Walther Oncology Center, Indiana University School of Medicine, Indianapolis; Walther Cancer Institute, Indianapolis, IN; the Department of Genetics, Hospital for Sick Children, Toronto, Ontario, Canada; and the Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, Canada.
Venue
Blood
Publisher
American Society of Hematology
Published
1998-06-01
Volume
91
Issue
11
Pages
4092-4098
ISSN
  • 1528-0020
  • 0006-4971
DOI
10.1182/blood.v91.11.4092
Cited by
151
References
0
Language
en

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