The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
GATA-1 and Erythropoietin Cooperate to Promote Erythroid Cell Survival by Regulating bcl-xL Expression
Abstract
The transcription factor GATA-1 is essential for normal erythropoiesis. By examining in vitro–differentiated embryonic stem cells, we showed previously that in the absence of GATA-1, committed erythroid precursors fail to complete maturation and instead undergo apoptosis. The mechanisms by which GATA-1 controls cell survival are unknown. Here we report that in erythroid cells, GATA-1 strongly induces the expression of the anti-apoptotic protein bcl-xL, but not the related proteins bcl-2 and mcl-1. Consistent with a role for bcl-xL in mediating GATA-1–induced erythroid cell survival, in vitro–differentiated bcl-xL−/− embryonic stem cells fail to generate viable mature definitive erythroid cells, a phenotype resembling that of GATA-1 gene disruption. In addition, we show that erythropoietin, which is also required for erythroid cell survival, cooperates with GATA-1 to stimulate bcl-xL gene expression and to maintain erythroid cell viability during terminal maturation. Together, our data show that bcl-xL is essential for normal erythroid development and suggest a regulatory hierarchy in which bcl-xL is a critical downstream effector of GATA-1 and erythropoietin-mediated signals.
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Cites
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Cited by
Fetal Anemia and Apoptosis of Red Cell Progenitors in Stat5a−/−5b−/− Mice
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Mitoferrin is essential for erythroid iron assimilation
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Self-citationProximity among Distant Regulatory Elements at the β-Globin Locus Requires GATA-1 and FOG-1
Vakoc, C. R., Letting, D. L., Gheldof, N., Sawado, T., Bender, M. A., Groudine, M., Weiss, M. J., Dekker, J., & Blobel, G. A. (2005) · Molecular Cell · doi:10.1016/j.molcel.2004.12.028 · Cited by 490
Self-citationGATA transcription factors in the developing and adult heart
PIKKARAINEN, S. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.03.025 · Cited by 416
Global regulation of erythroid gene expression by transcription factor GATA-1
Welch, J. J. (2004) · Blood · doi:10.1182/blood-2004-04-1603 · Cited by 411
Metadata
- Authors
- Gregory, T., Yu, C., Ma, A., Orkin, S. H., Blobel, G. A., & Weiss, M. J.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1999-07-01
- Volume
- 94
- Issue
- 1
- Pages
- 87-96
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W3719606
- Cited by
- 366
- References
- 57
- FWCI
- 9.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: GATA-1 and Erythropoietin Cooperate to Promote Erythroid Cell Survival by Regulating bcl-xL Expression. https://app.cochat.ai/papers/10.1182/blood.v94.1.87.413k41_87_96
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- Gregory, T., Yu, C., Ma, A., Orkin, S. H., Blobel, G. A., & Weiss, M. J. (1999). GATA-1 and Erythropoietin Cooperate to Promote Erythroid Cell Survival by Regulating bcl-xL Expression. Blood. https://doi.org/10.1182/blood.v94.1.87.413k41_87_96
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