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Single-tube multiplex-PCR screen for common deletional determinants of α-thalassemia
Abstract
-Thalassemia is very common throughout all tropical and subtropical regions of the world. In Southeast Asia and the Mediterranean regions, compound heterozygotes and homozygotes may have anemia that is mild to severe (hemoglobin [Hb] H disease) or lethal (Hb Bart's hydrops fetalis). We have developed a reliable, single-tube multiplex–polymerase chain reaction (PCR) assay for the 6 most frequently observed determinants of -thalassemia. The assay allows simple, high throughput genetic screening for these common hematological disorders. (Blood. 2000;95:360-362)
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Cited by
Harteveld, C. L., & Higgs, D. R. (2010) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-5-13 · Cited by 508
Self-citationCockburn, I. A., Mackinnon, M. J., O'Donnell, A., Allen, S. J., Moulds, J. M., Baisor, M., Bockarie, M., Reeder, J. C., & Rowe, J. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305306101 · Cited by 255
Ma, S., Cahalan, S., LaMonte, G., Grubaugh, N. D., Zeng, W., Murthy, S. E., Paytas, E., Gamini, R., Lukacs, V., Whitwam, T., et al. (2018) · Cell · doi:10.1016/j.cell.2018.02.047 · Cited by 250
Hemoglobin Variants and Disease Manifestations in Severe Falciparum Malaria
May, J., Evans, J. A., Timmann, C., Ehmen, C., Busch, W., Thye, T., Agbenyega, T., & Horstmann, R. D. (2007) · JAMA · doi:10.1001/jama.297.20.2220 · Cited by 184
The Molecular Basis of -Thalassemia
Higgs, D. R. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a011718 · Cited by 126
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Metadata
- Authors
- Chong, S. S., Boehm, C. D., Higgs, D. R., & Cutting, G. R.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2000-01-01
- Volume
- 95
- Issue
- 1
- Pages
- 360-362
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1585156201
- Cited by
- 480
- References
- 0
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chong, S. S., Boehm, C. D., Higgs, D. R., & Cutting, G. R. (2000). Single-tube multiplex-PCR screen for common deletional determinants of α-thalassemia. Blood. https://doi.org/10.1182/blood.v95.1.360
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