The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Development of lentiviral vectors for gene therapy for human diseases
Abstract
Retroviral vectors derived from murine retroviruses are being used in several clinical gene therapy trials. Recently, progress has been made in the development of vectors based on the lentivirus genus of retroviruses, which ironically includes a major human pathogen, human immunodeficiency virus (HIV). As these vector systems for clinical gene transfer are developed, it is important to understand the rationale behind their design and development. This article reviews the fundamental features of retrovirus replication and of the elements necessary for development of a retroviral vector system, and it discusses why vector systems based on HIV or other lentiviruses have the potential to become important tools in clinical gene therapy.
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Citations
Cites
In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector
Naldini, L., Blömer, U., Gallay, P., Ory, D., Mulligan, R., Gage, F. H., Verma, I. M., & Trono, D. (1996) · Science · doi:10.1126/science.272.5259.263 · Cited by 4,903
Cochrane, A. W., Chen, C. H., & Rosen, C. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.3.1198 · Cited by 165
Cited by
Titering lentiviral vectors: comparison of DNA, RNA and marker expression methods
Sastry, L., Johnson, T., Hobson, M. J., Smucker, B., & Cornetta, K. (2002) · Gene Therapy · doi:10.1038/sj.gt.3301731 · Cited by 295
Sieburg, M., Tripp, A., Ma, J.-W., & Feuer, G. (2004) · Journal of Virology · doi:10.1128/jvi.78.19.10399-10409.2004 · Cited by 40
Hager, S., Frame, F. M., Collins, A. T., Burns, J. E., & Maitland, N. J. (2008) · Human Gene Therapy · doi:10.1089/hum.2007.165 · Cited by 30
Phenotype correction of Fanconi anemia group A hematopoietic stem cells using lentiviral vector
Yamada, K., Ramezani, A., Hawley, R. G., Ebell, W., Arwert, F., Arnold, L. W., & Walsh, C. E. (2003) · Molecular Therapy · doi:10.1016/s1525-0016(03)00223-5 · Cited by 22
Metadata
- Authors
- Buchschacher, G. L., & Wong-Staal, F.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2000-04-15
- Volume
- 95
- Issue
- 8
- Pages
- 2499-2504
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1509401342
- Cited by
- 261
- References
- 2
- FWCI
- 16.88
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
