The DOI matches its Crossref record.
Expression of breast cancer resistance protein in blast cells from patients with acute leukemia
Abstract
Breast cancer resistance protein (BCRP) is a novel member of the adenosine triphosphate–binding cassette superfamily of transport proteins. Transfection and enforced expression of BCRP in drug-sensitive cells confer resistance to mitoxantrone, doxorubicin, daunorubicin, and topotecan. We studied blast cells from 21 acute leukemia patients (20 acute myeloid leukemia, 1 acute lymphocytic leukemia) for the expression of BCRP mRNA using a quantitative reverse-transcription polymerase chain reaction assay. BCRP mRNA expression varied more than 1000-fold among the samples tested, with low or barely detectable expression in half of the samples. Seven samples (33%) had relatively high expression of BCRP mRNA. High expression of BCRP did not correlate strongly with high expression of P-glycoprotein, suggesting that BCRP may cause resistance to certain antileukemic drugs in P-glycoprotein–negative cases. High expression of BCRP mRNA is sufficiently frequent in AML to warrant more extensive investigations to determine the relation of disease subtype and treatment outcome to BCRP expression and function.
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Citations
Cited by
Multidrug resistance in cancer: role of ATP–dependent transporters
Gottesman, M. M., Fojo, T., & Bates, S. E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc706 · Cited by 5,536
Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)
Austin Doyle, L., & Ross, D. D. (2003) · Oncogene · doi:10.1038/sj.onc.1206938 · Cited by 1,051
Self-citationABC Transporters as Phenotypic Markers and Functional Regulators of Stem Cells
Bunting, K. D. (2002) · STEM CELLS · doi:10.1002/stem.200011 · Cited by 458
Human bone marrow myeloma cells express RANKL.
Sezer, O., Heider, U., Jakob, C., Eucker, J., Possinger, K., & Roodman, G. D. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.20.1.353 · Cited by 104
Metadata
- Authors
- Ross, D. D., Karp, J. E., Chen, T. T., & Doyle, L. A.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2000-07-01
- Volume
- 96
- Issue
- 1
- Pages
- 365-368
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2414957002
- Cited by
- 250
- References
- 0
- FWCI
- 9.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ross, D. D., Karp, J. E., Chen, T. T., & Doyle, L. A. (2000). Expression of breast cancer resistance protein in blast cells from patients with acute leukemia. Blood. https://doi.org/10.1182/blood.v96.1.365
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