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Prevalence and outcomes of diabetes, hypertension and cardiovascular disease in COPD

Mannino, D. M., Thorn, D., Swensen, A., Holguin, F.·2008·European Respiratory Journal

Abstract

Chronic obstructive pulmonary disease (COPD) is associated with important chronic comorbid diseases, including cardiovascular disease, diabetes and hypertension. The present study analysed data from 20,296 subjects aged ≥45 yrs at baseline in the Atherosclerosis Risk in Communities Study (ARIC) and the Cardiovascular Health Study (CHS). The sample was stratified based on baseline lung function data, according to modified Global Initiative for Obstructive Lung Disease (GOLD) criteria. Comorbid disease at baseline and death and hospitalisations over a 5-yr follow-up were then searched for. Lung function impairment was found to be associated with more comorbid disease. In logistic regression models adjusting for age, sex, race, smoking, body mass index and education, subjects with GOLD stage 3 or 4 COPD had a higher prevalence of diabetes (odds ratio (OR) 1.5, 95% confidence interval (CI) 1.1–1.9), hypertension (OR 1.6, 95% CI 1.3–1.9) and cardiovascular disease (OR 2.4, 95% CI 1.9–3.0). Comorbid disease was associated with a higher risk of hospitalisation and mortality that was worse in people with impaired lung function. Lung function impairment is associated with a higher risk of comorbid disease, which contributes to a higher risk of adverse outcomes of mortality and hospitalisations.

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Metadata

Authors
Mannino, D. M., Thorn, D., Swensen, A., & Holguin, F.
Venue
European Respiratory Journal
Published
2008-06-25
Volume
32
Issue
4
Pages
962-969
ISSN
  • 0903-1936 (ISSN-L)
  • 1399-3003
OpenAlex
W2169927995
Cited by
1,184
References
4
FWCI
27.82
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Prevalence and outcomes of diabetes, hypertension and cardiovascular disease in COPD. https://app.cochat.ai/papers/10.1183/09031936.00012408
The paper
Mannino, D. M., Thorn, D., Swensen, A., & Holguin, F. (2008). Prevalence and outcomes of diabetes, hypertension and cardiovascular disease in COPD. European Respiratory Journal. https://doi.org/10.1183/09031936.00012408

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.