Quadriceps Myostatin Expression in COPD
Open accessAbstract
To the Editors: Quadriceps muscle dysfunction is well recognised in chronic obstructive pulmonary disease (COPD), and is associated with impaired exercise capacity and increased mortality 1. Functionally, the quadriceps is characterised by reduced strength, increased fatigability and decreased endurance, associated with muscle fibre atrophy and a switch towards more glycolytic muscle fibres (types 1–2). The underlying molecular mechanisms of quadriceps dysfunction in COPD are not well clarified. Myostatin is a member of the transforming growth factor-β family, and is a potent negative regulator of muscle mass, as demonstrated in naturally occurring animal and human genetic mutations, and genetic murine models 2. Myostatin may therefore be a candidate regulator of muscle mass in disorders characterised by muscle atrophy, including COPD. Few data exist regarding myostatin in COPD, but a recent cross-sectional study showed a three-fold increase in vastus lateralis myostatin mRNA transcripts in COPD patients with significant quadriceps weakness compared to healthy controls 3. However, the relationship between quadriceps myostatin expression and functional characteristics of the muscle is not known. We hypothesised that myostatin expression would negatively correlate with quadriceps strength and exercise capacity in COPD. 18 patients with COPD were enrolled from clinics at the Royal Brompton Hospital (London, UK). Exclusion criteria included exacerbation in the previous 4 weeks, coexisting heart, renal or liver failure, or a systemic inflammatory or metabolic disorder. 16 healthy, age-matched controls were recruited by advertisement. All participants gave written informed consent and the protocol was approved by the local Research Ethics Committee. The following were measured in study participants: lung function tests; fat-free mass index, calculated from bioelectrical impedance and normalised to height squared; quadriceps muscle strength, assessed by measuring supine isometric maximal voluntary contraction (MVC) of the leg ipsilateral to the dominant hand and corrected for body mass index (MVC/BMI); quadriceps …
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Myostatin expression is increased in the quadriceps of COPD patients, possibly related to hypoxia.
“Its expression is increased in the quadriceps of COPD patients [176], possibly related to hypoxia [72].”
From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [176]
In “Quadriceps myostatin expression in COPD” (page unavailable), the paper reports increased quadriceps myostatin expression in some COPD patients with low strength, exercise capacity, or physical activity—not in COPD patients generally. The hypoxia explanation is attached to a different citation [72] and is not judged here. (LLM, conf=0.88)
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Cites
Double muscling in cattle due to mutations in the myostatin gene
McPherron, A. C., & Lee, S.-J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12457 · Cited by 2,039 · see citing works
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Research works printed but not linked: 10
- [1]Swallow EB Reyes D Hopkinson NS Quadriceps strength predicts mortality in patients with moderate to severe chronic obstructive pulmonary disease Thorax 2007 62 115 120 17090575 PMC2111256
- [2]McPherron AC Lawler AM Lee SJ Regulation of skeletal muscle mass in mice by a new TGF-β superfamily member Nature 1997 387 83 90 9139826
- [3]Plant PJ Brooks D Faughnan M Cellular markers of muscle atrophy in chronic obstructive pulmonary disease (COPD) Am J Respir Cell Mol Biol 2009 42 461 471 19520920
- [4]Swallow EB Gosker HR Ward KA A novel technique for nonvolitional assessment of quadriceps muscle endurance in humans J Appl Physiol 2007 103 739 746 17569771
- [5]ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories ATS statement: guidelines for the six-minute walk test Am J Respir Crit Care Med 2002 166 111 117 12091180
- [7]Carlson CJ Booth FW Gordon SE Skeletal muscle myostatin mRNA expression is fiber-type specific and increases during hindlimb unloading Am J Physiol 1999 277 R601 606 10444569
- [8]Gilson H Schakman O Combaret L Myostatin gene deletion prevents glucocorticoid-induced muscle atrophy Endocrinology 2007 148 452 460 17038559
- [9]Lewis MI Fournier M Storer TW Skeletal muscle adaptations to testosterone and resistance training in men with COPD J Appl Physiol 2007 103 1299 1310 17673568
- [10]Troosters T Probst VS Crul T Resistance Training Prevents Deterioration in Quadriceps Muscle Function During Acute Exacerbations of COPD Am J Respir Crit Care Med 2010 181 1016 1017 20133927
- [11]Wagner KR Fleckenstein JL Amato AA A phase I/II trial of MYO-029 in adult subjects with muscular dystrophy Ann Neurol 2008 63 561 571 18335515
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Myostatin: more than just a regulator of muscle mass
Argilés, J. M., Orpí, M., Busquets, S., & López-Soriano, F. J. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.02.001 · Cited by 125 · see citing works
Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting
Henrot, P., Dupin, I., Schilfarth, P., Esteves, P., Blervaque, L., Zysman, M., Gouzi, F., Hayot, M., Pomiès, P., & Berger, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076454 · Cited by 85 · see citing works
“Its expression is increased in the quadriceps of COPD patients [176], possibly related to hypoxia [72].”
Background
- Authors
- D-C. Man, W., Natanek, S. A., Riddoch-Contreras, J., Lewis, A., Marsh, G. S., Kemp, P. R., & Polkey, M. I.
- Affiliations
- Royal Brompton & Harefield NHS Foundation Trust (GB)
- Imperial College London (GB)
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2010-08-31
- Volume
- 36
- Issue
- 3
- Pages
- 686-688
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- PMC
- PMC3039204
- OpenAlex
- W2065405654
- Cited by
- 48
- References
- 1
- Citations by year
- 2024: 2 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 8 · 2013: 3 · 2012: 6
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Respiratory Journal (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Wellcome Trust (079686)
- Royal Brompton and Harefield NHS Foundation Trust
- National Institute for Health and Care Research (DHCS/07/07/009)
- Imperial College London
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- chronic obstructive pulmonary disease, myostatin, quadriceps, muscle atrophy, muscle strength, exercise capacity, vastus lateralis, maximal voluntary contraction, fat-free mass
- MeSH terms
- Aged, Cross-Sectional Studies, Female, Gene Expression Regulation, Humans, Inflammation, Male, Middle Aged, Muscular Atrophy, Phenotype, RNA, Messenger, Transforming Growth Factor beta, Pulmonary Disease, Chronic Obstructive, Quadriceps Muscle, Myostatin
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