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Cited by 144Chronic Obstructive Pulmonary Disease (COPD) ResearchMuscle Physiology and DisordersMitochondrial Function and Pathology

Mitochondrial Dysfunction in COPD Patients with Low Body Mass Index

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Rabinovich, R. A., Bastos, R., Ardite, E., Llinàs, L., Orozco-Levi, M., Gea, J., Vilaró, J., Barberà, J. A. +3 more·2007·European Respiratory Journal
DOI 10.1183/09031936.00086306
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Abstract

Patients with chronic obstructive pulmonary disease (COPD) show abnormal adaptations of skeletal muscle redox status after exercise training. Increased skeletal muscle oxidative stress in COPD patients may prompt mitochondrial dysfunction. The present study explores the association between body composition and mitochondrial respiration in seven COPD patients with low body mass index (BMI(L)), eight COPD patients with normal body mass index (BMI(N)) and seven healthy controls. All of them underwent a vastus lateralis biopsy in which muscle structure, in vitro mitochondrial respiratory function, uncoupling protein 3 (UCP3) mRNA expression and glutathione levels in both isolated mitochondria and the whole muscle were determined. Mitochondrial respiratory function (assessed by acceptor control ratio (ACR)) was impaired in BMI(L) (2.2+/-0.6) compared with both BMI(N) (5.3+/-1.3) and controls (8.2+/-1.3). ACR significantly correlated with arterial oxygen tension and with muscle endurance but it showed a negative association with exercise-induced increase in blood lactate levels. UCP3 mRNA expression was reduced in BMI(L) patients. In conclusion, chronic obstructive pulmonary disease patients with low body mass index show electron transport chain dysfunction, which may contribute to low muscle endurance in the current subgroup of patients.

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  • In isolated mitochondria, state 3:CII respiration is diminished in low-BMI COPD patients compared to both normal BMI and healthy subjects.

    “The first study was performed in isolated mitochondria and showed a diminished state 3:CII respiration in low-body-mass-index (BMI) COPD patients compared to both normal BMI and healthy subjects [99].”

    From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [99]

    The Mitochondrial respiration results report lower state 3 respiration in low-BMI COPD patients than in healthy controls. Its mean was also lower than in normal-BMI COPD patients, but that comparison was not statistically significant. The claim presents the difference from both groups as a demonstrated finding; the significant difference from both groups was for ACR, not state 3 respiration. No page number is provided in our copy. (LLM, conf=0.89)

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Authors
Rabinovich, R. A., Bastos, R., Ardite, E., Llinàs, L., Orozco-Levi, M., Gea, J., Vilaró, J., Barberà, J. A., Rodríguez-Roisin, R., Fernández-Checa, J. C., & Roca, J.
Affiliations
  • University of Groningen (NL)
  • Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
  • University Medical Center Groningen (NL)
  • Consejo Superior de Investigaciones Científicas (ES)
ORCID
Venue
European Respiratory Journal
Publisher
European Respiratory Society (ERS)
Published
2006-12-20
Volume
29
Issue
4
Pages
643-650
ISSN
  • 0903-1936 (ISSN-L)
  • 1399-3003
DOI
10.1183/09031936.00086306
OpenAlex
W2116936653
Cited by
144
References
51
Citations by year
2026: 3 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 6 · 2021: 4 · 2020: 8 · 2019: 12 · 2018: 5 · 2017: 5 · 2016: 5 · 2015: 10 · 2014: 13 · 2013: 13 · 2012: 9
FWCI
8.16
Type
journal article
Language
en
Open access
Locations
  • European Respiratory Journal (publishedVersion)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
  • INFM-OAR (INFN Catania) (submittedVersion, other-oa)
Funders
  • Universitat de Barcelona
  • Universitat Ramon Llull
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords
chronic obstructive pulmonary disease, low body mass index, mitochondrial dysfunction, mitochondrial respiration, UCP3, glutathione, vastus lateralis, body composition, exercise-induced lactate, muscular endurance, electron transport chain
MeSH terms
Aged, Biopsy, Body Composition, Glutathione, Humans, Male, Middle Aged, Mitochondria, Muscle, Oxidation-Reduction, Physical Endurance, RNA, Messenger, Exercise, Body Mass Index, Pulmonary Disease, Chronic Obstructive, Quadriceps Muscle

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