Performance of Xpert MTB/RIF on pleural tissue for the diagnosis of pleural tuberculosis
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Performance of Xpert MTB/RIF on pleural tissue for the diagnosis of pleural tuberculosisTo the Editor:Tuberculosis (TB) remains the second leading cause of death from an infectious disease in adults.Extrapulmonary TB (EPTB) accounts for about 25% of all cases of active TB.Pleural TB is the second most common manifestation of EPTB.Existing tests for the diagnosis of pleural TB have major limitations in terms of accuracy, time to diagnosis and drug resistance testing, and require special expertise for sample acquisition and interpretation of the results.Biopsy of the pleural tissue for combined histological examination and culture is considered the diagnostic gold standard, albeit imperfect [1, 2].
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In pleural tissue, Xpert MTB/RIF sensitivity against a composite reference standard was 0% (0 to 23).
“In pleural tissue, Xpert MTB/RIF sensitivity and specificity against a composite reference standard were 0% (0 to 23) and 98% (87 to 100) (1 study; 55 participants; Christopher 2013); Figure 12.”
From Xpert MTB/RIF Ultra and Xpert MTB/RIF assays for extrapulmonary tuberculosis and rifampicin resistance in adults (2021) · cites this paper as Christopher 2013
In pleural tissue, Xpert MTB/RIF specificity against a composite reference standard was 98% (87 to 100).
“In pleural tissue, Xpert MTB/RIF sensitivity and specificity against a composite reference standard were 0% (0 to 23) and 98% (87 to 100) (1 study; 55 participants; Christopher 2013); Figure 12.”
From Xpert MTB/RIF Ultra and Xpert MTB/RIF assays for extrapulmonary tuberculosis and rifampicin resistance in adults (2021) · cites this paper as Christopher 2013
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References 13 · Cited by 60
- Authors
- Christopher, D. J., Schumacher, S. G., Michael, J. S., Luo, R., Balamugesh, T., Duraikannan, P., Pollock, N. R., Pai, M., & Denkinger, C. M.
- Affiliations
- Christian Medical College, Vellore (IN)
- McGill University (CA)
- Stanford University (US)
- Boston Children's Hospital (US)
- Beth Israel Deaconess Medical Center (US)
- ORCID
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2013-07-30
- Volume
- 42
- Issue
- 5
- Pages
- 1427-1429
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2127751319
- Cited by
- 60
- References
- 13
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 14 · 2020: 5 · 2019: 4 · 2018: 6 · 2017: 4 · 2016: 3 · 2015: 4 · 2014: 6 · 2013: 1
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Respiratory Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Christian Medical College, Vellore
- Canadian Institutes of Health Research (MOP-89918)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pleural and Pulmonary Diseases
- Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
- Keywords
- Xpert MTB/RIF, pleural tuberculosis, extrapulmonary tuberculosis, molecular diagnosis, Mycobacterium tuberculosis detection, rifampicin resistance, diagnostic accuracy
- MeSH terms
- Adult, Female, Humans, Male, Middle Aged, Pleural Effusion, Predictive Value of Tests, Reagent Kits, Diagnostic, Reference Standards, Sensitivity and Specificity, Tuberculosis, Pleural, Reproducibility of Results, Tuberculosis, Multidrug-Resistant, Clinical Laboratory Techniques
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