The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Desferrioxamine attenuates minor lung injury following surgical acute liver failure
Open accessAbstract
Acute liver failure (ALF) can be complicated by lung dysfunction. The aim of this study was to test the hypothesis that inhibition of oxidative stress through iron chelation with desferrioxamine (DFX) attenuates pulmonary injury caused by ALF. 14 adult female domestic pigs were subjected to surgical devascularisation of the liver and were randomised to a study group (DFX group, n = 7), which received post-operative intravenous infusion of DFX (14.5 mg·kg−1·h−1 for the first 6 h post-operatively and 2.4 mg·kg−1·h−1 until completion of 24 h), and a control group (n = 7). Post-operative lung damage was evaluated by histological and bronchoalveolar lavage fluid (BALF) analysis. DFX resulted in reduced BALF protein levels and tissue phospholipase (PL)A 2 activity. Plasma malondialdehyde and BALF nitrate and nitrite concentrations were lower, while catalase activity in the lung was higher after DFX treatment. PLA 2, platelet-activating factor acetylhydrolase and total cell counts in BALF did not differ between groups. Histological examination revealed reduced alveolar collapse, pneumonocyte necrosis and total lung injury in the DFX-treated animals. DFX reduced systemic and pulmonary oxidative stress during ALF. The limited activity of PLA 2 and the attenuation of pneumonocyte necrosis could represent beneficial mechanisms by which DFX improves alveolar–capillary membrane permeability and prevents alveolar space collapse.
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“Using the same model, the researchers also demonstrated that application of DFO significantly reduced brain edema, intracranial pressure, and lung injury [71, 72].”
From The utility of iron chelators in the management of inflammatory disorders (2015) · cites this paper as [72]
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PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
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Oxidative Stress and Acute Lung Injury
Chow, C.-W., Herrera Abreu, M. T., Suzuki, T., & Downey, G. P. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.f278 · Cited by 372
Oxidant-Antioxidant Balance in Acute Lung Injury*
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Evidence for a Hydrostatic Mechanism in Human Neurogenic Pulmonary Edema
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Zhu, S., Ware, L. B., Geiser, T., Matthay, M. A., & Matalon, S. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.1.2005068 · Cited by 167
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Cited by
The utility of iron chelators in the management of inflammatory disorders
Lehmann, C., Islam, S., Jarosch, S., Zhou, J., Hoskin, D., Greenshields, A., Al-Banna, N., Sharawy, N., Sczcesniak, A., Kelly, M., et al. (2015) · Mediators of Inflammation · doi:10.1155/2015/516740 · Cited by 54
“permeability, and prevented alveolar space collapse [72]”
MethodVlahakos, D., Arkadopoulos, N., Kostopanagiotou, G., Siasiakou, S., Kaklamanis, L., Degiannis, D., Demonakou, M., & Smyrniotis, V. (2012) · Artificial Organs · doi:10.1111/j.1525-1594.2011.01385.x · Cited by 51
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Metadata
- Authors
- Kostopanagiotou, G. G., Kalimeris, K. A., Arkadopoulos, N. P., Pafiti, A., Panagopoulos, D., Smyrniotis, V., Vlahakos, D., Routsi, C., Lekka, M. E., & Nakos, G.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- University of Ioannina (GR)
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2008-12-01
- Volume
- 33
- Issue
- 6
- Pages
- 1429-1436
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2127565019
- Cited by
- 32
- References
- 32
- Citations by year
- 2024: 1 · 2023: 3 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 5 · 2014: 4 · 2013: 2 · 2012: 2
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Respiratory Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Social Fund
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Keywords
- deferoxamine, acute liver failure, lung injury, iron chelation, oxidative stress, phospholipase A2, alveolar-capillary permeability, alveolar collapse, catalase, malondialdehyde, lipoprotein-associated phospholipase A2, bronchoalveolar lavage fluid
- MeSH terms
- Analysis of Variance, Animals, Bronchoalveolar Lavage Fluid, Catalase, Deferoxamine, Female, Infusions, Intravenous, Malondialdehyde, Necrosis, Nitrates, Nitrites, Proteins, Random Allocation, Swine, Liver Failure, Acute, Oxidative Stress, Phospholipases A2, Acute Lung Injury
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- Kostopanagiotou, G. G., Kalimeris, K. A., Arkadopoulos, N. P., Pafiti, A., Panagopoulos, D., Smyrniotis, V., Vlahakos, D., Routsi, C., Lekka, M. E., & Nakos, G. (2009). Desferrioxamine attenuates minor lung injury following surgical acute liver failure. European Respiratory Journal. https://doi.org/10.1183/09031936.00123108
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
