The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Serum surfactant protein D is steroid sensitive and associated with exacerbations of COPD
Open accessAbstract
Surfactant protein (SP)-D is a lung-derived protein that has been proposed as a biomarker for inflammatory lung disease. Serum SP-D was evaluated as a biomarker for components of chronic obstructive pulmonary disease (COPD) in the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) cohort and its response assessed to the administration of the anti-inflammatory agent prednisolone. The median level of serum SP-D was significantly elevated in 1,888 individuals with COPD compared to 296 current and former smokers without airflow obstruction (121.1 and 114.3 ng·mL −1 , respectively; p = 0.021) and 201 nonsmokers (82.2 ng·ml −1 ; p<0.001). There was no correlation with the severity of COPD. Individuals with COPD who had a serum SP-D concentration that was greater than the 95th percentile of nonsmokers (175.4 ng·mL −1 ) showed an increased risk of exacerbations over the following 12 months (adjusted OR 1.30; 95% CI 1.03–1.63). Treatment with 20 mg·day −1 prednisolone for 4 weeks resulted in a fall in serum SP-D levels (126.0 to 82.1 ng·mL −1 ; p<0.001) but no significant change in post-bronchodilator forced expiratory volume in 1 s. Serum SP-D concentration is raised in smokers and may be useful in identifying individuals who are at increased risk of exacerbations of COPD. It may represent an intermediate measure for the development of novel anti-inflammatory agents.
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Cites
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Vestbo, J., Hurd, S. S., Agustí, A. G., Jones, P. W., Vogelmeier, C., Anzueto, A., Barnes, P. J., Fabbri, L. M., Martinez, F. J., Nishimura, M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0596pp · Cited by 15,983
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Infections and Airway Inflammation in Chronic Obstructive Pulmonary Disease Severe Exacerbations
Papi, A., Bellettato, C. M., Braccioni, F., Romagnoli, M., Casolari, P., Caramori, G., Fabbri, L. M., & Johnston, S. L. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200506-859oc · Cited by 1,072
Surfactant proteins SP-A and SP-D: structure, function and receptors
Kishore, U., Greenhough, T. J., Waters, P., Shrive, A. K., Ghai, R., Kamran, M. F., Bernal, A. L., Reid, K. B. M., Madan, T., & Chakraborty, T. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2005.08.004 · Cited by 523
Serum Amyloid A Is a Biomarker of Acute Exacerbations of Chronic Obstructive Pulmonary Disease
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Cited by
Celli, B. R., Locantore, N., Yates, J., Tal-Singer, R., Miller, B. E., Bakke, P., Calverley, P., Coxson, H., Crim, C., Edwards, L. D., et al. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201110-1792oc · Cited by 432
Self-citationCOPDGene Investigators, Hobbs, B. D., ECLIPSE Investigators, LifeLines Investigators, SPIROMICS Research Group, International COPD Genetics Network Investigators, UK BiLEVE Investigators, International COPD Genetics Consortium, de Jong, K., Lamontagne, M., et al. (2017) · Nature Genetics · doi:10.1038/ng.3752 · Cited by 398
Self-citationHe, X., Ji, J., Zheng, D., Luo, Z., Luo, L., & Guo, L. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1450798 · Cited by 15
Metadata
- Authors
- Lomas, D. A., Silverman, E. K., Edwards, L. D., Locantore, N. W., Miller, B. E., Horstman, D. H., & Tal-Singer, R.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2009-01-22
- Volume
- 34
- Issue
- 1
- Pages
- 95-102
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2135702050
- Cited by
- 235
- References
- 6
- FWCI
- 19.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lomas, D. A., Silverman, E. K., Edwards, L. D., Locantore, N. W., Miller, B. E., Horstman, D. H., & Tal-Singer, R. (2009). Serum surfactant protein D is steroid sensitive and associated with exacerbations of COPD. European Respiratory Journal. https://doi.org/10.1183/09031936.00156508
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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