The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Airway smooth muscle thickness in asthma is related to severity but not duration of asthma
Open accessAbstract
Asthma is characterised by an increased airway smooth muscle (ASM) area (ASM area) within the airway wall. The present study examined the relationship of factors including severity and duration of asthma to ASM area. The perimeter of the basement membrane (PBM) and ASM area were measured on transverse sections of large and small airways from post mortem cases of fatal (n = 107) and nonfatal asthma (n = 37) and from control subjects (n = 69). The thickness of ASM (ASM area/PBM) was compared between asthma groups using multivariate linear regression. When all airways were considered together, ASM area/PBM (in millimetres) was increased in nonfatal (median 0.04; interquartile range 0.013–0.051; p = 0.034) and fatal cases of asthma (0.048; 0.025–0.078; p<0.001) compared with controls (0.036; 0.024–0.042). Compared with cases of nonfatal asthma, ASM area/PBM was greater in cases of fatal asthma in large (p<0.001) and medium (p<0.001), but not small, airways. ASM area/PBM was not related to duration of asthma, age of onset of asthma, sex or smoking. No effect due to study centre, other than that due to sampling strategy, was found. The thickness of the ASM layer is increased in asthma and is related to the severity of asthma but not its duration.
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Citations
Cites
A longitudinal, population-based, cohort study of childhood asthma followed to adulthood
Sears, M. R., Greene, J. M., Willan, A. R., Wiecek, E. M., Taylor, D. R., Flannery, E. M., Cowan, J. O., Herbison, G. P., Silva, P. A., & Poulton, R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022363 · Cited by 1,460
Decline in Lung Function in the Busselton Health Study
James, A. L., Palmer, L. J., Kicic, E., Maxwell, P. S., Lagan, S. E., Ryan, G. F., & Musk, A. W. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200402-230oc · Cited by 397
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Cited by
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
Chung, K. F., Wenzel, S. E., Brozek, J. L., Bush, A., Castro, M., Sterk, P. J., Adcock, I. M., Bateman, E. D., Bel, E. H., Bleecker, E. R., et al. (2014) · European Respiratory Journal · doi:10.1183/09031936.00202013 · Cited by 3,926
Self-citationTGF-β Signaling in Lung Health and Disease
Saito, A., Horie, M., & Nagase, T. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082460 · Cited by 490
Mechanisms of Airway Remodeling
Hirota, N., & Martin, J. G. (2013) · Chest · doi:10.1378/chest.12-3073 · Cited by 324
Metadata
- Authors
- James, A. L., Bai, T. R., Mauad, T., Abramson, M. J., Dolhnikoff, M., McKay, K. O., Maxwell, P. S., Elliot, J. G., & Green, F. H.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2009-03-12
- Volume
- 34
- Issue
- 5
- Pages
- 1040-1045
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2155650191
- Cited by
- 178
- References
- 2
- FWCI
- 6.30
- Type
- journal article
- Language
- en
- Open access
- bronze
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- James, A. L., Bai, T. R., Mauad, T., Abramson, M. J., Dolhnikoff, M., McKay, K. O., Maxwell, P. S., Elliot, J. G., & Green, F. H. (2009). Airway smooth muscle thickness in asthma is related to severity but not duration of asthma. European Respiratory Journal. https://doi.org/10.1183/09031936.00181608
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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