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Cited by 555

The DOI matches its Crossref record; 137 of the 137 references it cites were found in a registry or an index.

Asthma and cigarette smoking

Open access
Thomson, N.C., Chaudhuri, R., Livingston, E.·2004·European Respiratory Journal
DOI 10.1183/09031936.04.00039004
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Abstract

In most developed countries ∼25% of adults with asthma are current cigarette smokers. Asthma and active cigarette smoking interact to cause more severe symptoms, accelerated decline in lung function, and impaired short-term therapeutic response to corticosteroids. Cigarette smoking may modify inflammation that is associated with asthma, although there is limited published data on airway pathology in smokers with asthma. To date, the evidence points towards a combination of both heightened and suppressed inflammatory responses in smokers compared with nonsmokers with asthma. The mechanisms of corticosteroid resistance in asthmatic smokers are unexplained, but could be as a result of alterations in airway inflammatory cell phenotypes (e.g.increased neutrophils or reduced eosinophils), changes in the glucocorticoid receptor-α to -β ratio (e.g.overexpression of glucocorticoid receptor β), and increased activation of pro-inflammatory transcription factors (e.g.nuclear factor-κB) or reduced histone deacetylase activity. In conclusion, every effort should be made to encourage asthmatics who smoke to stop, although the effects of smoking cessation upon reversing the adverse effects of tobacco smoke on asthma control, therapeutic response to corticosteroids and airway pathology have yet to be fully elucidated. Alternative or additional therapies to inhaled corticosteroids are needed for asthmatic patients who are unable to quit smoking.

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Metadata

Authors
Thomson, N. C., Chaudhuri, R., & Livingston, E.
Venue
European Respiratory Journal
Publisher
European Respiratory Society (ERS)
Published
2004-11
Volume
24
Issue
5
Pages
822-833
ISSN
  • 0903-1936 (ISSN-L)
  • 1399-3003
DOI
10.1183/09031936.04.00039004
OpenAlex
W2162913726
Cited by
555
References
137
FWCI
11.02
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Asthma and cigarette smoking. https://app.cochat.ai/papers/10.1183/09031936.04.00039004
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Thomson, N. C., Chaudhuri, R., & Livingston, E. (2004). Asthma and cigarette smoking. European Respiratory Journal. https://doi.org/10.1183/09031936.04.00039004

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.