Cited by 206Chronic Obstructive Pulmonary Disease (COPD) ResearchAsthma and respiratory diseasesAdvanced Chemical Sensor Technologies

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Exhaled nitric oxide from lung periphery is increased in COPD

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Brindicci, C., Ito, K., Resta, O., Pride, N. B., Barnes, P. J., Kharitonov, S. A.·2005·European Respiratory Journal

DOI 10.1183/09031936.04.00125304

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Abstract

Single constant flow exhaled nitric oxide (eNO) cannot distinguish between the sources of NO. The present study measured eNO at multiple expired flows (MEFeNO) to partition NO into alveolar (Calv,NO) and bronchial (Jaw,NO) fractions to investigate peripheral lung contribution to eNO in chronic obstructive lung disease (COPD). MEFeNO were made in 81 subjects including 18 nonsmokers, 16 smokers and 47 COPD patients of different severity by the classification of the Global Initiative for Chronic Obstructive Lung Disease (GOLD): 0 (n = 14), 1 (n = 7), 2 (n = 11), 3 (n = 8) and 4 (n = 7). COPD severity was correlated with an increased Calv,NO regardless of the patient's smoking habit or current treatment. The levels of Calv,NO (in ppb) were 1.4+/-0.09 in nonsmokers, 2.1+/-0.1 in smokers categorised as GOLD stage 0 (smokers-GOLD0), 3.3+/-0.18 in GOLD1-2 and 3.4+/-0.1 in GOLD3-4. Jaw,NO levels (pL x s(-1)) were higher in nonsmokers than smokers-GOLD0 (716.2+/-33.3 versus 464.7+/-41.8), GOLD3-4 (609.4+/-71). Diffusion of NO in the airways (Daw,NO pL x ppb(-1) s(-1)) was higher (p<0.05) in GOLD3-4 than in nonsmokers (15+/-1.2 versus 11+/-0.5) and smokers-GOLD0 (11.6+/-0.5). MEFeNO measurements were reproducible, free from day-to-day and diurnal variation and were not affected by bronchodilators. In conclusion, chronic obstructive pulmonary disease is associated with elevated alveolar nitric oxide. Measurements of nitric oxide at multiple expired flows may be useful in monitoring inflammation and progression of chronic obstructive pulmonary disease, and the response to anti-inflammatory treatment.

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Kharitonov, S. A., Yates, D. H., Robbins, R. A., Barnes, P. J., Logan-Sinclair, R., & Shinebourne, E. A. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90931-8 · Cited by 1,432
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Fabbri, L. M., Romagnoli, M., Corbetta, L., Casoni, G. L., Busljetic, K., Turato, G., Ligabue, G., Ciaccia, A., Saetta, M. P., & Papi, A. A. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200203-183oc · Cited by 508
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Tsoukias, N. M., & George, S. C. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.2.653 · Cited by 477
Marked Flow-Dependence of Exhaled Nitric Oxide Using a New Technique to Exclude Nasal Nitric Oxide
Silkoff, P. E., McClean, P. A., Slutsky, A. S., Furlott, H., Hoffstein, E., Wakita, S., Chapman, K. R., Szalai, J. P., & Zamel, N. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.1.9001322 · Cited by 469
Increase in Reactive Nitrogen Species Production in Chronic Obstructive Pulmonary Disease Airways
Ichinose, M., Sugiura, H., Yamagata, S., Koarai, A., & Shirato, K. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.2.9908132 · Cited by 347
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Maziak, W., Loukides, S., Culpitt, S. V., SULLIVAN, P., Kharitonov, S. A., & Barnes, P. J. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.3.97-05009 · Cited by 323
Reproducibility of exhaled nitric oxide measurements in healthy and asthmatic adults and children
Kharitonov, S. A., Gonio, F., Kelly, C., Meah, S., & Barnes, P. J. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00066903a · Cited by 316
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Show all 29 references

Research works printed but not linked: 4

2004, Swiss Med Wkly, 134, 175
2002, Eur Respir J, 20, 95s
2002, Eur Respir J, 20, 174s
1998, Mod Pathol, 11, 648

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Authors: Brindicci, C., Ito, K., Resta, O., Pride, N. B., Barnes, P. J., & Kharitonov, S. A.
Affiliations: Imperial College London (GB)
University of Bari Aldo Moro (IT)
Corresponding author: Kharitonov, S. A.
ORCID: Ito, K.
Resta, O.
Barnes, P. J.
Venue: European Respiratory Journal
Publisher: European Respiratory Society (ERS)
Published: 2005-07
Volume: 26
Issue: 1
Pages: 52-59
ISSN: 0903-1936 (ISSN-L)
1399-3003
DOI: 10.1183/09031936.04.00125304
OpenAlex: W2164167422
Cited by: 206
References: 29
Citations by year: 2026: 3 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 8 · 2019: 6 · 2018: 11 · 2017: 6 · 2016: 3 · 2015: 9 · 2014: 5 · 2013: 14 · 2012: 14
FWCI: 11.90
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: European Respiratory Journal (publishedVersion)
PubMed (publishedVersion)
CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Physical Sciences › Engineering › Biomedical Engineering › Advanced Chemical Sensor Technologies
Keywords: exhaled nitric oxide, chronic obstructive pulmonary disease, alveolar nitric oxide, COPD severity, smoking, airway inflammation
MeSH terms: Adult, Aged, Analysis of Variance, Female, Forced Expiratory Volume, Humans, Male, Middle Aged, Nitric Oxide, Probability, Prognosis, Reference Values, Respiratory Function Tests, Sensitivity and Specificity, Severity of Illness Index, Smoking, Cohort Studies, Biomarkers, Case-Control Studies, Risk Assessment, Statistics, Nonparametric, Pulmonary Disease, Chronic Obstructive, Exhalation

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Exhaled nitric oxide from lung periphery is increased in COPD

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